| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Brian White, John D Sterrett, Zoya Grigoryan, Lauren Lally, Jared D Heinze, Hyder Alikhan, Christopher A Lowry, Lark J Perez, Joshua DeSipio and Sangita Phadtare |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Camden Health Research Initiative grant to Sangita Phadtare |
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| Corresponding Author |
Sangita Phadtare, BSc, MSc, PhD, Professor, Department of Biomedical Sciences, Cooper Medical School of Rowan University, 401 S Broadway, Camden, NJ 08103, United States. phadtare@rowan.edu |
| Key Words |
Gut microbiome; Metabolome; Helicobacter pylori; Antibiotic resistance; Dysbiosis; Eradication |
| Core Tip |
Helicobacter pylori (H. pylori) infects half of the world’s population and is associated with various diseases, including malignancy. Research of microbiome and metabolomic changes associated with H. pylori may hold therapeutic potential. We sought to characterize the fecal microbiome and fatty acid metabolism among H. pylori patients in our community. We observed differences in alpha and beta diversity among H. pylori patients compared to controls, particularly for those over 40 years old. Changes in several fecal fatty acids, including those associated with anti-inflammatory activity, were observed. Our findings may have implications for improving H. pylori eradication and minimizing associated negative distal outcomes. |
| Publish Date |
2021-09-03 11:45 |
| Citation |
White B, Sterrett J, Grigoryan Z, Lally L, Heinze J, Alikhan H, Lowry C, Perez LJ, DeSipio J, Phadtare S. Characterization of gut microbiome and metabolome in Helicobacter pylori patients in an underprivileged community in the United States. World J Gastroenterol 2021; 27(33): 5575-5594 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i33/5575.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i33.5575 |
