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8/23/2022 9:54:46 AM | Browse: 187 | Download: 366
Publication Name World Journal of Clinical Oncology
Manuscript ID 66823
Country/Territory Singapore
Received
2021-04-07 16:24
Peer-Review Started
2021-04-07 16:28
To Make the First Decision
Return for Revision
2021-06-28 08:43
Revised
2021-08-08 18:59
Second Decision
2022-07-13 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-18 00:14
Articles in Press
2022-07-18 00:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-07-09 04:05
Typeset the Manuscript
2022-08-17 09:34
Publish the Manuscript Online
2022-08-23 09:54
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Prospective Study
Article Title Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer
Manuscript Source Invited Manuscript
All Author List Ern-Yu Tan, Lavina Bharwani, Yee-Hong Chia, Richie C T Soong, Sherylyn S Y Lee, Juliana J C Chen and Patrick M Y Chan
ORCID
Author(s) ORCID Number
Ern-Yu Tan http://orcid.org/0000-0001-7726-3974
Lavina Bharwani http://orcid.org/0000-0002-3974-6374
Yee-Hong Chia http://orcid.org/0000-0002-6872-8933
Richie C T Soong http://orcid.org/0000-0002-0152-1225
Sherylyn S Y Lee http://orcid.org/0000-0002-4176-597X
Juliana J C Chen http://orcid.org/0000-0002-4882-9235
Patrick M Y Chan http://orcid.org/0000-0003-3294-0382
Funding Agency and Grant Number
Funding Agency Grant Number
NHG-KTPH Small Innovative Grants (SIG) SIG/11009
NHG-KTPH Small Innovative Grants (SIG) SIG/15025
Corresponding Author Ern-Yu Tan, DPhil, FRCS (Gen Surg), MBBS, Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. ern_yu_tan@ttsh.com.sg
Key Words Functional cytochrome P450 2D6 polymorphisms; Breast cancer; Hormonal therapy
Core Tip We studied the role of cytochrome P450 2D6 (CYP2D6) polymorphisms in guiding the selection of hormonal agents in women with hormone-responsive breast cancer. The CYP2D6 intermediate metabolizer phenotype was highly prevalent in our women, while the poor metabolizer phenotype was rare. We did not observe any significant association between the CYP2D6 phenotypes and recurrence-free or overall survival in our study, although it could be because most women opted for aromatase inhibitors regardless of CYP2D6 phenotype. There was a non-significant trend towards better survival associated with aromatase inhibitor use over tamoxifen.
Publish Date 2022-08-23 09:54
Citation Tan EY, Bharwani L, Chia YH, Soong RCT, Lee SSY, Chen JJC, Chan PMY. Impact of cytochrome P450 2D6 polymorphisms on decision-making and clinical outcomes in adjuvant hormonal therapy for breast cancer. World J Clin Oncol 2022; 13(8): 712-724
URL https://www.wjgnet.com/2218-4333/full/v13/i8/712.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i8.712
Full Article (PDF) WJCO-13-712.pdf
Full Article (Word) WJCO-13-712.docx
Manuscript File 66823_Auto_Edited-ZMG-Filipodia-LS.docx
Answering Reviewers 66823-Answering reviewers.pdf
Audio Core Tip 66823-Audio core tip.m4a
Biostatistics Review Certificate 66823-Biostatistics statement.pdf
Clinical Trial Registration Statement 66823-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 66823-Conflict-of-interest statement.pdf
Copyright License Agreement 66823-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 66823-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 66823-Institutional review board statement.pdf
Peer-review Report 66823-Peer-review(s).pdf
Scientific Misconduct Check 66823-CrossCheck.png
Scientific Misconduct Check 66823-Bing-Gong ZM-2.png
Scientific Editor Work List 66823-Scientific editor work list.pdf