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9/1/2014 5:04:00 PM | Browse: 907 | Download: 744
Publication Name World Journal of Gastroenterology
Manuscript ID 6692
Country/Territory Japan
Received
2013-10-27 11:05
Peer-Review Started
2013-10-28 11:55
To Make the First Decision
2013-11-13 15:35
Return for Revision
2013-11-14 16:22
Revised
2013-11-22 15:52
Second Decision
2014-01-08 18:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-08 18:37
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-02-26 14:46
Publish the Manuscript Online
2014-03-12 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Topic Highlights
Article Title Autoantibodies in primary biliary cirrhosis: Recent progress in research on the pathogenetic and clinical significance
Manuscript Source Invited Manuscript
All Author List Satoshi Yamagiwa, Hiroteru Kamimura, Masaaki Takamura and Yutaka Aoyagi
Funding Agency and Grant Number
Corresponding Author Satoshi Yamagiwa, MD, PhD, Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi-dori 1, Chuo-ku, Niigata 951-8510, Japan. syamagi@med.niigata-u.ac.jp
Key Words Primary biliary cirrhosis; Autoantibodies; Anti-mitochondrial antibodies; Anticentromere antibodies; Anti-gp210 antibodies.
Core Tip While the presence of antimitochondrial antibodies is pathognomonic to Primary biliary cirrhosis (PBC), more than 60 autoantibodies have been detected in patients with PBC. Antinuclear antibodies (ANA) become positive in approximately 30% to 50% of patients with PBC. Among ANA, anti-gp210 and anticentromere antibodies have been indicated as significant prognostic markers. Previous studies have shown that unique characteristics of biliary epithelial cells during apoptosis may result in the presence of a direct and specific immune response to mitochondrial autoantigens. Moreover, recent studies have indicated that chemicals originating from the environment are associated with a breakdown in the tolerance against mitochondrial autoantigens.
Publish Date 2014-03-12 14:46
Citation Yamagiwa S, Kamimura H, Takamura M, Aoyagi Y. Autoantibodies in primary biliary cirrhosis: Recent progress in research on the pathogenetic and clinical significance. World J Gastroenterol 2014; 20(10): 2606-2612
URL http://www.wjgnet.com/1007-9327/full/v20/i10/2606.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i10.2606
Full Article (PDF) WJG-20-2606.pdf
Full Article (Word) WJG-20-2606.doc
Manuscript File 6692-Review.docx
Answering Reviewers 6692-Answering reviewers.pdf
Copyright License Agreement 6692-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6692-Language certificate.pdf
Peer-review Report 6692-Peer review(s).pdf
Scientific Editor Work List 6692-Scientific editor work list.doc