Publication Name	World Journal of Gastroenterology
Manuscript ID	67180
Country	Italy

Received	2021-04-17 10:56
Peer-Review Started	2021-04-17 10:59
To Make the First Decision
Return for Revision	2021-06-03 19:12
Revised	2021-06-30 07:54
Second Decision	2021-08-13 02:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-13 08:05
Articles in Press	2021-08-13 08:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-24 04:15
Typeset the Manuscript	2021-09-18 01:23
Publish the Manuscript Online	2021-09-23 07:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Treatment of hepatitis B virus infection in children and adolescents
Manuscript Source	Invited Manuscript
All Author List	Mariangela Stinco, Chiara Rubino, Sandra Trapani and Giuseppe Indolfi
ORCID	Author(s) ORCID Number Mariangela Stinco http://orcid.org/0000-0003-3970-5000 Chiara Rubino http://orcid.org/0000-0001-7480-3613 Sandra Trapani http://orcid.org/0000-0003-1105-1500 Giuseppe Indolfi http://orcid.org/0000-0003-3830-9823
Funding Agency and Grant Number
Corresponding Author	Giuseppe Indolfi, MD, Professor, Department Neurofarba, University of Florence and Meyer Children’s University Hospital, 6 Gaetano Pieraccini, Florence 50139, Italy. giuseppe.indolfi@meyer.it
Key Words	Hepatitis B; Children; Adolescents; Antiviral therapy; Tenofovir disoproxil fumarate; Entecavir; Interferon
Core Tip	Hepatitis B virus (HBV) is a major cause of acute and chronic liver disease. During childhood asymptomatic chronic hepatitis B is the most common outcome of the infection and a conservative approach is usually recommended. In selected patients there is a strict indication for treatment. Different drugs have been approved by United States Food and Drug Administration and European Medicines Agency for treatment of children and adolescents with chronic HBV infection. The main goal of the treatment is to reduce the risk of progression to cirrhosis and hepatocellular carcinoma through the suppression of HBV replication.
Publish Date	2021-09-23 07:48
Citation	Stinco M, Rubino C, Trapani S, Indolfi G. Treatment of hepatitis B virus infection in children and adolescents. World J Gastroenterol 2021; 27(36): 6053-6063
URL	https://www.wjgnet.com/1007-9327/full/v27/i36/6053.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i36.6053

Full Article (PDF)	WJG-27-6053.pdf
Full Article (Word)	WJG-27-6053.docx
Manuscript File	67180-Review-FilipodiaCL.docx
Answering Reviewers	67180-Answering reviewers.pdf
Audio Core Tip	67180-Audio core tip.ogg
Conflict-of-Interest Disclosure Form	67180-Conflict-of-interest statement.pdf
Copyright License Agreement	67180-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67180-Language certificate.pdf
Peer-review Report	67180-Peer-review(s).pdf
Scientific Misconduct Check	67180-CrossCheck.png
Scientific Misconduct Check	67180-Bing-Gong ZM-2.png
Scientific Misconduct Check	67180-Scientific misconduct check.pdf
Scientific Editor Work List	67180-Scientific editor work list.pdf