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10/29/2014 7:34:00 PM | Browse: 1458 | Download: 1474
Publication Name World Journal of Gastroenterology
Manuscript ID 6729
Country/Territory Spain
Received
2013-10-27 22:39
Peer-Review Started
2013-10-28 14:10
To Make the First Decision
2014-01-15 17:05
Return for Revision
2014-01-17 16:37
Revised
Second Decision
2014-05-29 20:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-29 20:49
Articles in Press
2014-05-29 21:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-06-11 16:38
Typeset the Manuscript
2014-10-15 19:00
Publish the Manuscript Online
2014-10-29 19:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General & Internal
Manuscript Type Topic Highlights
Article Title Alcoholism: A systemic proinflammatory condition
Manuscript Source Invited Manuscript
All Author List Emilio González-Reimers, Francisco Santolaria-Fernández, María Candelaria Martín-González, Camino María Fernández-Rodríguez and Geraldine Quintero-Platt
Funding Agency and Grant Number
Corresponding Author Emilio González-Reimers, MD, PhD, Professor, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Ctra. Ofra, s/n, Tenerife, 38320 Canary Islands, Spain. egonrey@ull.es
Key Words Alcoholism; Cytokines; Brain; Bone; Muscle; Oxidative damage; Atherosclerosis; Sepsis; Lung; Chronic pancreatitis; Alcoholic liver disease
Core Tip Alcoholism is a multisystemic disease. In the last ten years it has been shown that an inflammatory response is triggered by ethanol itself, by reactive oxygen species derived from ethanol metabolism, and by increased amounts of mainly Gram-negative bacteria that reach liver and peripheral organs due to ethanol-induced increased intestinal permeability. In addition to direct organ injury caused by ethanol itself, these mechanisms especially affect end organs such as brain, lung, muscle, bone, heart, blood vessels, pancreas, and the immune system. The main features of these effects are highlighted in this review.
Publish Date 2014-10-29 19:34
Citation González-Reimers E, Santolaria-Fernández F, Martín-González MC, Fernández-Rodríguez CM, Quintero-Platt G. Alcoholism: A systemic proinflammatory condition. World J Gastroenterol 2014; 20(40): 14660-14671
URL http://www.wjgnet.com/1007-9327/full/v20/i40/14660.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i40.14660
Full Article (PDF) WJG-20-14660.pdf
Full Article (Word) WJG-20-14660.doc
Manuscript File 6729-Review.doc
Answering Reviewers 6729-Answering reviewers.pdf
Copyright License Agreement 6729-Copyright assignment.pdf
Peer-review Report 6729-Peer review(s).pdf
Scientific Misconduct Check 6729-CrossCheck.jpg
Scientific Editor Work List 6729-Scientific editor work list.pdf