| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Frontier |
| Article Title |
Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alain Couvineau, Thierry Voisin, Pascal Nicole, Valerie Gratio and Anne Blais |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| INSERM U1149/The Inflammation Research Center, Inserm Transfert, The Institut National du Cancer |
2013-213 |
| Ligue Nationale Contre le Cancer |
R16020HH, GB/MA/CD/EP-12062 |
| AgroParisTech (INRAE and Université Paris-Saclay) |
|
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| Corresponding Author |
Alain Couvineau, PhD, Academic Research, INSERM UMR1149/Inflammation Research Center, Team “From inflammation to cancer in digestive diseases” labeled by “la Ligue Nationale contre le Cancer”, University of Paris, DHU UNITY, 16 rue Henri Huchard, Paris 75018, France. alain.couvineau@inserm.fr |
| Key Words |
Orexin; Neuropeptide; G-protein coupled receptor superfamily; Inflammation; Metabolic syndrome; Cancer |
| Core Tip |
Twenty years ago, hypothalamic orexin peptides hypocretin-1/orexin-A and hypocretin-2/orexin-B) and their receptors were identified. They belong to the G-protein coupled receptor superfamily. Orexins and their receptors were involved in the regulation of many functions in the central nervous system: the regulation of wakefulness, drug addictions, food consumption, energy homeostasis and stress. However, various biological effects have been also identified in the peripheral nervous system including endocrine and cardiovascular functions. Orexins/orexin receptors have been shown to play a major role in various peripheral diseases encompassing chronic inflammation and cancers. The present review focuses on the impact of orexin exogenous administration, in various pathophysiological conditions including digestive cancers, intestinal bowel disease, septic shock, multiple sclerosis and metabolic syndrome. |
| Publish Date |
2021-11-25 07:42 |
| Citation |
Couvineau A, Voisin T, Nicole P, Gratio V, Blais A. Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions. World J Gastroenterol 2021; 27(44): 7582-7596 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i44/7582.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i44.7582 |
