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Articles Published Processes
5/10/2022 9:43:36 AM | Browse: 226 | Download: 537
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Received |
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2021-04-20 13:48 |
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Peer-Review Started |
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2021-04-20 13:50 |
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To Make the First Decision |
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Return for Revision |
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2021-08-19 18:53 |
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Revised |
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2021-09-17 04:43 |
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Second Decision |
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2022-03-28 05:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-04-04 06:04 |
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Articles in Press |
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2022-04-04 06:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-03-24 18:09 |
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Typeset the Manuscript |
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2022-04-27 10:20 |
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Publish the Manuscript Online |
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2022-05-10 09:43 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ling-Yu Chu, Bin-Liang Huang, Xu-Chun Huang, Yu-Hui Peng, Jian-Jun Xie and Yi-Wei Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
81972801 |
| Guangdong Basic and Applied Basic Research Foundation |
2019A1515011873 |
| Medical Project of Science and Technology Planning of Shantou |
200605115266724 |
| 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant |
2020LKSFG01B |
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| Corresponding Author |
Yi-Wei Xu, PhD, Research Associate, Department of Clinical Laboratory Medicine, The Cancer Hospital of Shantou University Medical College, No. 7 Raoping road, Shantou 515041, Guangdong Province, China. 14yyxu@stu.edu.cn |
| Key Words |
EFNA1; Expression; Tumorigenesis; Clinical implication; gastrointestinal cancer |
| Core Tip |
Ephrin-A1, a protein that in humans is encoded by the EFNA1 gene, is the ligand of EphA2. Studies have shown that the EphA2 receptor and its ligand ephrin-A1 are expressed in a variety of malignant tumors and the interaction between the two promotes the migration of tumor vascular endothelial cells. In addition, studies have shown that EFNA1 widely affects tumor growth through enhancing tumor angiogenesis, malignant cell events and invasiveness. EFNA1 is also up-regulated in gastrointestinal tumors and is closely related to the prognosis of gastrointestinal tumors. Therefore, this article reviews the expression, prognostic value, regulation and clinical significance of EFNA1 in gastrointestinal tumors. |
| Publish Date |
2022-05-10 09:43 |
| Citation |
Chu LY, Huang BL, Huang XC, Peng YH, Xie JJ, Xu YW. EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance. World J Gastrointest Oncol 2022; 14(5): 973-988 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i5/973.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i5.973 |
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