Publication Name	World Journal of Hepatology
Manuscript ID	67387
Country	Bulgaria

Received	2021-04-22 22:49
Peer-Review Started	2021-04-22 22:51
To Make the First Decision
Return for Revision	2021-06-15 21:59
Revised	2021-07-09 13:24
Second Decision	2021-11-16 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-18 06:43
Articles in Press	2021-11-18 06:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-13 08:53
Publish the Manuscript Online	2021-12-27 05:24

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19
Manuscript Source	Invited Manuscript
All Author List	Gergana Taneva, Dimitar Dimitrov and Tsvetelina Velikova
ORCID	Author(s) ORCID Number Gergana Taneva http://orcid.org/0000-0002-8916-6415 Dimitar Dimitrov http://orcid.org/0000-0002-72146434 Tsvetelina Velikova http://orcid.org/0000-0002-0593-1272
Funding Agency and Grant Number
Corresponding Author	Tsvetelina Velikova, MD, PhD, Assistant Professor, Department of Clinical Immunology, University Hospital Lozenetz, Kozyak 1 Str., Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg
Key Words	Liver dysfunction; Liver damage; Cytokine storm; Prognostic factor; COVID-19; Severe COVID-19; SARS-CoV-2; Aspartate aminotransferase; Alanine aminotransferase; Bilirubin; Interleukin-6
Core Tip	Looking at the liver tests in patients with severe coronavirus disease 2019 (COVID-19), C-reactive protein (CRP) showed a strong correlation with the aspartate aminotransferase (AST) levels. This was observed in both intensive care units (ICU) and non-ICU patients. However, CRP levels were higher in non-ICU patients with liver damage, whereas alanine aminotransferase (ALT) was higher in ICU COVID-19 patients. Thus, like interleukin-6 (IL-6), ferritin, and CRP correlated directly with AST and ALT levels in non-ICU patients, there is a direct correlation of IL-6 and acute phase proteins with AST in severe COVID-19 cases. These observations confirm the critical impact of systemic inflammation and specifically elevated IL-6 during severe acute respiratory coronavirus 2 cytokine storm on liver injury.
Publish Date	2021-12-27 05:24
Citation	Taneva G, Dimitrov D, Velikova T. Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19. World J Hepatol 2021; 13(12): 2005-2012
URL	https://www.wjgnet.com/1948-5182/full/v13/i12/2005.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i12.2005

Full Article (PDF)	WJH-13-2005.pdf
Full Article (Word)	WJH-13-2005.docx
Manuscript File	67387_Auto_Edited.docx
Answering Reviewers	67387-Answering reviewers.pdf
Audio Core Tip	67387-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67387-Conflict-of-interest statement.pdf
Copyright License Agreement	67387-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67387-Language certificate.pdf
Peer-review Report	67387-Peer-review(s).pdf
Scientific Editor Work List	67387-Scientific editor work list.pdf