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12/3/2021 7:34:23 AM | Browse: 441 | Download: 1415
Publication Name World Journal of Gastroenterology
Manuscript ID 67541
Country/Territory Brazil
Received
2021-04-28 01:12
Peer-Review Started
2021-04-28 01:14
To Make the First Decision
Return for Revision
2021-06-13 02:03
Revised
2021-07-06 15:00
Second Decision
2021-11-19 03:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-11-21 19:55
Articles in Press
2021-11-21 19:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-24 23:35
Publish the Manuscript Online
2021-12-03 07:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Clinical and Translational Research
Article Title MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers
Manuscript Source Invited Manuscript
All Author List Ana Elisa Valencise Quaglio, Felipe Jose Santaella, Maria Aparecida Marchesan Rodrigues, Ligia Yukie Sassaki and Luiz Claudio Di Stasi
ORCID
Author(s) ORCID Number
Ana Elisa Valencise Quaglio http://orcid.org/0000-0002-5998-2382
Felipe Jose Santaella http://orcid.org/0000-0001-9496-2582
Maria Aparecida Marchesan Rodrigues http://orcid.org/0000-0002-8355-1929
Ligia Yukie Sassaki http://orcid.org/0000-0002-7319-8906
Luiz Claudio Di Stasi http://orcid.org/0000-0002-7864-1073
Funding Agency and Grant Number
Funding Agency Grant Number
São Paulo Research Foundation (FAPESP) 2017/03959-8
São Paulo Research Foundation (FAPESP) 2015/15267-8
Corresponding Author Ana Elisa Valencise Quaglio, PhD, Professor, Research Scientist, Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTec), Department of Biophysics and Pharmacology, São Paulo State University (Unesp), Institute of Biosciences, R. Prof. Dr. Antônio Celso Wagner Zanin, 250 - Distrito de Rubião Junior, Botucatu 18618-689, São Paulo, Brazil. anaequaglio@hotmail.com
Key Words Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; miRNA; Differential diagnosis; Biomarker
Core Tip This study identified 27 microRNAs (miRNAs) with significantly different expression levels between Crohn’s disease (CD) and ulcerative colitis (UC) patients. Five miRNAs whose expression levels were significantly lower in the UC patients than in the CD patients were selected for enrichment analysis, which revealed enrichment in certain signaling pathways that were mostly associated with cancer-related processes. The characterization and comparison of the differentially expressed miRNAs in this study could lead to novel diagnostic biomarkers to differentiate UC from CD. These markers might also predict prognosis, help elucidate the distinct pathophysiology of each disease, and lead to novel therapeutic target identification.
Publish Date 2021-12-03 07:34
Citation Quaglio AEV, Santaella FJ, Rodrigues MAM, Sassaki LY, Di Stasi LC. MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers. World J Gastroenterol 2021; 27(45): 7801-7812
URL https://www.wjgnet.com/1007-9327/full/v27/i45/7801.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i45.7801
Full Article (PDF) WJG-27-7801.pdf
Full Article (Word) WJG-27-7801.docx
Manuscript File 67541_Auto_Edited.docx
Answering Reviewers 67541-Answering reviewers.pdf
Audio Core Tip 67541-Audio core tip.mp3
Biostatistics Review Certificate 67541-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 67541-Conflict-of-interest statement.pdf
Copyright License Agreement 67541-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 67541-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 67541-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 67541-Language certificate.pdf
Supplementary Material 67541-Supplementary material.pdf
Peer-review Report 67541-Peer-review(s).pdf
Scientific Misconduct Check 67541-Bing-Liu M-1.png
Scientific Misconduct Check 67541-Bing-Wu YXJ-2.png
Scientific Editor Work List 67541-Scientific editor work list.pdf