| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Lin Xiao, Li-Ping Ma, Da-Feng Yang, Mei Yang, Zhen-Yu Li and Mei-Fang Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81770358 |
| National Natural Science Foundation of China |
81000140 |
| Natural Science Foundation of Hunan Province |
2017JJ3486 |
| the Fund for Health Care in Hunan Province |
B2017-01 |
| National Natural Science Foundation of China |
82000339 |
|
| Corresponding Author |
Mei-Fang Chen, MD, PhD, Associate Professor, Department of Geriatric Cardiology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. meifang121@sohu.com |
| Key Words |
Advanced glycation end products; Profilin-1; Diabetic macroangiopathy; Atherosclerosis; Vascular remodeling; Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway |
| Core Tip |
The formation and accumulation of advanced glycation end products (AGEs) contributes to accelerated macrovascular complications in individuals with diabetes. Currently, few studies have examined the role of profilin-1 in vasculopathy induced by AGEs. The present study proved that AGEs induced proatherogenic events such as vascular smooth muscle cell proliferation, proatherogenic mediator expression and vascular remodeling, changes that were attenuated by silencing profilin-1 gene expression. These data suggested for the first time that profilin-1 was involved in AGEs-induced aortic atheroma formation in rats, indicating that drugs targeting profilin-1 may become a potential therapeutic strategy for ameliorating atherosclerosis secondary to diabetes. |
| Publish Date |
2021-11-15 08:09 |
| Citation |
Xiao ZL, Ma LP, Yang DF, Yang M, Li ZY, Chen MF. Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation. World J Diabetes 2021; 12(11): 1875-1893 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i11/1875.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i11.1875 |
