Publication Name	World Journal of Gastroenterology
Manuscript ID	6772
Country	Greece

Received	2013-10-29 08:49
Peer-Review Started	2013-10-29 21:23
To Make the First Decision	2013-12-16 17:42
Return for Revision	2013-12-18 14:46
Revised	2014-01-01 01:00
Second Decision	2014-03-05 14:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-05 15:09
Articles in Press	2014-05-23 11:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-30 17:24
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	HBeAg negative variants and their role in the natural history of chronic hepatitis B virus infection
Manuscript Source	Invited Manuscript
All Author List	Alexandra Alexopoulou and Peter Karayiannis
Funding Agency and Grant Number
Corresponding Author	Dr. Alexandra Alexopoulou, 2nd Department of Medicine, Medical School, University of Athens, Hippokration General Hospital, 40 Konstantinoupoleos Str., Hilioupolis, 16342 Athens, Greece. alexopou@ath.forthnet.gr
Key Words	Precore stop codon variants; basal core promoter variants; hepatitis B e antigen negative chronic hepatitis B; Re-activation; Hepatitis B virus-DNA replication
Core Tip	Chronic hepatitis B virus infection can in turn go through the immune tolerant, the immune clearance, the inactive or low replicative and the reactivation phases. hepatitis B e antigen (HBeAg) positivity characterises the first two phases. Seroconversion from HBeAg to the corresponding antibody is the result of the appearance of the precore and basal core promoter variants, which either abrogate or lead to reduced HBeAg levels. The absence of HBeAg eliminates its tolerogenic effect on the immune system which thus becomes activated, leading to seroconversion. The reasons why some patients then enter into the reactivation phase during which the variants are the dominant virus present remain unexplained.
Publish Date	2014-06-27 10:37
Citation	Alexopoulou A, Karayiannis P. HBeAg negative variants and their role in the natural history of chronic hepatitis B virus infection. World J Gastroenterol 2014; 20(24): 7644-7652
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7644.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7644

Full Article (PDF)	WJG-20-7644.pdf
Full Article (Word)	WJG-20-7644.doc
Manuscript File	6772-Review.docx
Answering Reviewers	6772-Answering review(s).pdf
Copyright License Agreement	6772-Copyright assignment.pdf
Peer-review Report	6772-Peer review(s).pdf
Scientific Editor Work List	6772-Scientific editor work list.doc