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9/10/2021 12:09:57 PM | Browse: 30 | Download: 58
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 67956
Country/Territory China
Received
2021-05-08 00:24
Peer-Review Started
2021-05-08 00:27
To Make the First Decision
Return for Revision
2021-06-16 01:41
Revised
2021-06-29 08:56
Second Decision
2021-07-29 02:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-29 07:32
Articles in Press
2021-07-29 07:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-08-09 04:02
Typeset the Manuscript
2021-08-19 00:59
Publish the Manuscript Online
2021-09-10 12:09
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Characterization of metabolic landscape in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Jing Wu, Ran Xue, Rong-Tao Jiang and Qing-Hua Meng
ORCID
Author(s) ORCID Number
Jing Wu http://orcid.org/0000-0003-1597-0387
Ran Xue http://orcid.org/0000-0003-3978-6066
Rong-Tao Jiang http://orcid.org/0000-0003-4657-0079
Qing-Hua Meng http://orcid.org/0000-0001-9967-6403
Funding Agency and Grant Number
Funding Agency Grant Number
The Municipal Natural Science Foundation of Beijing, China 7192085
National Science and Technology Major Project of China 2018ZX10302206-003-007
National Science and Technology Major Project of China 2017ZX10203202-001-005
The Capital Health Research and Development of Special 2018-1-3011
National Natural Science Foundation of China 81470877
Corresponding Author Qing-Hua Meng, MD, Chief Physician, Professor, Department of Medical Oncology, Beijing You-An Hospital, Capital Medical University, No. 8, Xi Tou Tiao, Youanmen Wai, Fengtai District, Beijing 100069, China. meng_qh0805@ccmu.edu.cn
Key Words Hepatocellular carcinoma; Metabolic reprogramming; Glycolysis; Lipid metabolism; Glutamine addiction; Diagnosis and treatment
Core Tip Metabolic activities play a crucial role in promoting tumor transformation and progression. In the current review, we present a summary of recent advances investigating the metabolic traits of hepatocellular carcinoma (HCC) with a specific focus on three common metabolic alterations involving glycolysis, lipid metabolism, and glutamine addiction, and describe some representative diagnostic markers or tools, and promising treatment agents. Moreover, challenges related to the existence of great heterogeneity in HCC, the ignorance of study-related confounders, and a lack of validation of proposed markers are discussed.
Publish Date 2021-09-10 12:09
Citation Wu J, Xue R, Jiang RT, Meng QH. Characterization of metabolic landscape in hepatocellular carcinoma. World J Gastrointest Oncol 2021; 13(9): 1144-1156
URL https://www.wjgnet.com/1948-5204/full/v13/i9/1144.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i9.1144
Full Article (PDF) WJGO-13-1144.pdf
Full Article (Word) WJGO-13-1144.docx
Manuscript File 67956_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers 67956-Answering reviewers.pdf
Audio Core Tip 67956-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 67956-Conflict-of-interest statement.pdf
Copyright License Agreement 67956-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 67956-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 67956-Language certificate.pdf
Supplementary Material 67956-Supplementary material.pdf
Peer-review Report 67956-Peer-review(s).pdf
Scientific Misconduct Check 67956-Bing-Fan JR-2.png
Scientific Misconduct Check 67956-Scientific misconduct check.pdf
Scientific Editor Work List 67956-Scientific editor work list.pdf