| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Cognitive disorder and dementia in type 2 diabetes mellitus
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Genaro G Ortiz, Miguel Huerta, Héctor A González-Usigli, Erandis D Torres-Sánchez, Daniela LC Delgado-Lara, Fermín P Pacheco-Moisés, Mario A Mireles-Ramírez, Blanca MG Torres-Mendoza, Roxana I Moreno-Cih and Irma E Velázquez-Brizuela |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Genaro G Ortiz, MD, PhD, Professor, Senior Researcher, Department of Philosophical and Methodological Disciplines, University Health Sciences Center, University of Guadalajara, 800 Sierra Mojada St., Guadalajara 44340, Jalisco, Mexico. genarogabriel@yahoo.com |
| Key Words |
Alzheimer´s disease; Diabetes mellitus; Insulin; Vascular dementia; Cognitive decline |
| Core Tip |
Cognitive disorders and dementia have multiple causes and clinical manifestations. Recently, defects in insulin signaling in the brain have been associated with cognitive disorders and dementia. In this regard, insulin signaling pathways in the brain regulate learning and memory, and modulate peripheral energy metabolism. In this review, the pathophysiological factors involved in cognitive disorders, dementia, and diabetes mellitus, and the link between these disorders, are presented in a summarized manner. Finally, we discuss the role of mitochondrial dysfunction in Alzheimer´s disease and diabetes mellitus. |
| Publish Date |
2022-04-14 11:27 |
| Citation |
Ortiz GG, Huerta M, González-Usigli HA, Torres-Sánchez ED, Delgado-Lara DL, Pacheco-Moisés FP, Mireles-Ramírez MA, Torres-Mendoza BM, Moreno-Cih RI, Velázquez-Brizuela IE. Cognitive disorder and dementia in type 2 diabetes mellitus. World J Diabetes 2022; 13(4): 319-337 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i4/319.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i4.319 |
