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12/27/2021 5:24:00 AM | Browse: 286 | Download: 480
Publication Name World Journal of Hepatology
Manuscript ID 68321
Country/Territory Italy
Received
2021-05-27 12:27
Peer-Review Started
2021-05-27 12:27
To Make the First Decision
Return for Revision
2021-07-06 01:59
Revised
2021-07-07 14:40
Second Decision
2021-11-22 03:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-11-25 02:26
Articles in Press
2021-11-25 02:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-12-13 08:56
Publish the Manuscript Online
2021-12-27 05:24
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Retrospective Study
Article Title Use of oral vancomycin in children with autoimmune liver disease: A single centre experience
Manuscript Source Invited Manuscript
All Author List Angelo Di Giorgio, Anna Tulone, Emanuele Nicastro, Lorenzo Norsa, Aurelio Sonzogni and Lorenzo D'Antiga
ORCID
Author(s) ORCID Number
Angelo Di Giorgio http://orcid.org/0000-0003-0363-5565
Anna Tulone http://orcid.org/0000-0002-7112-2182
Emanuele Nicastro http://orcid.org/0000-0002-4518-9375
Lorenzo Norsa http://orcid.org/0000-0003-3322-2921
Aurelio Sonzogni http://orcid.org/0000-0001-5001-9533
Lorenzo D'Antiga http://orcid.org/0000-0001-7150-3148
Funding Agency and Grant Number
Corresponding Author Angelo Di Giorgio, MD, PhD, N/A, Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII , Piazza Oms 1, Bergamo 24127, Italy. adigiorgio@asst-pg23.it
Key Words Autoimmune hepatitis; Autoimmune sclerosing cholangitis; Autoimmune liver disease; Vancomycin; Children; Liver transplantation
Core Tip Experience with oral vancomycin in children with autoimmune liver disease (AILD) is limited. We enrolled 75 children [median age 10.5 years (5.6-13.4)], 54 with autoimmune hepatitis and 21 with autoimmune sclerosing cholangitis; 63/75 achieved remission by standard immunosuppressive (IS) therapy, whereas 12/75 (16%) required oral vancomycin treatment (OVT). In 6/12 patients (50%) the response was complete, whereas it was partial in 2/12 (17%), and absent in 4/12 (33%). Overall OVT increased the remission rate of the whole group of AILD patients from 81% to 92%. OVT may represent a valuable treatment option in children with AILD who do not respond to standard IS.
Publish Date 2021-12-27 05:24
Citation Di Giorgio A, Tulone A, Nicastro E, Norsa L, Sonzogni A, D'Antiga L. Use of oral vancomycin in children with autoimmune liver disease: A single centre experience. World J Hepatol 2021; 13(12): 2113-2127
URL https://www.wjgnet.com/1948-5182/full/v13/i12/2113.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i12.2113
Full Article (PDF) WJH-13-2113.pdf
Full Article (Word) WJH-13-2113.docx
Manuscript File 68321_Auto_Edited.docx
Answering Reviewers 68321-Answering reviewers.pdf
Audio Core Tip 68321-Audio core tip.mp3
Biostatistics Review Certificate 68321-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 68321-Conflict-of-interest statement.pdf
Copyright License Agreement 68321-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 68321-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 68321-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 68321-Language certificate.pdf
Peer-review Report 68321-Peer-review(s).pdf
Scientific Misconduct Check 68321-Bing-Wang JJ-2.png