Publication Name	World Journal of Hepatology
Manuscript ID	68417
Country	India

Received	2021-05-22 09:49
Peer-Review Started	2021-05-22 09:54
To Make the First Decision
Return for Revision	2021-07-27 02:29
Revised	2021-08-19 17:00
Second Decision	2021-11-04 03:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-04 23:08
Articles in Press	2021-11-04 23:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-13 08:57
Publish the Manuscript Online	2021-12-27 05:24

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Newer variants of progressive familial intrahepatic cholestasis
Manuscript Source	Invited Manuscript
All Author List	Vignesh Vinayagamoorthy, Anshu Srivastava and Moinak Sen Sarma
ORCID	Author(s) ORCID Number Vignesh Vinayagamoorthy http://orcid.org/0000-0003-4860-683X Anshu Srivastava http://orcid.org/0000-0003-0902-4140 Moinak Sen Sarma http://orcid.org/0000-0003-2015-4069
Funding Agency and Grant Number
Corresponding Author	Anshu Srivastava, MD, Professor, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. avanianshu@yahoo.com
Key Words	Progressive familial intrahepatic cholestasis; Tight junction protein; Hepatocellular carcinoma; Biliary diversion; Microvillous inclusion disease
Core Tip	Progressive familial intrahepatic cholestasis (PFIC) manifests with a varying spectrum of clinical features, with some variants progressing rapidly into end stage liver disease. Recently, newer variants of PFIC have been described including PFIC 4 due to tight junction protein 2 (TJP2) mutation, PFIC 5 due to NR1H4 mutation and MYO5B related cholestasis also sometimes known as PFIC 6. TJP2 related PFIC also has a risk of hepatocellular carcinoma. This article describes the pathogenesis and clinical features of the newer variants of PFIC.
Publish Date	2021-12-27 05:24
Citation	Vinayagamoorthy V, Srivastava A, Sarma MS. Newer variants of progressive familial intrahepatic cholestasis. World J Hepatol 2021; 13(12): 2024-2038
URL	https://www.wjgnet.com/1948-5182/full/v13/i12/2024.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i12.2024

Full Article (PDF)	WJH-13-2024.pdf
Full Article (Word)	WJH-13-2024.docx
Manuscript File	68417_Auto_Edited.docx
Answering Reviewers	68417-Answering reviewers.pdf
Audio Core Tip	68417-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	68417-Conflict-of-interest statement.pdf
Copyright License Agreement	68417-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	68417-Language certificate.pdf
Peer-review Report	68417-Peer-review(s).pdf
Scientific Editor Work List	68417-Scientific editor work list.pdf