Publication Name	World Journal of Gastroenterology
Manuscript ID	6846
Country	Germany

Received	2013-10-29 15:10
Peer-Review Started	2013-10-30 21:35
To Make the First Decision	2013-12-04 08:49
Return for Revision	2013-12-04 19:40
Revised	2014-02-20 15:16
Second Decision	2014-04-09 09:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-09 10:59
Articles in Press	2014-05-23 10:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-25 16:25
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver zonation: Novel aspects of its regulation and its impact on homeostasis
Manuscript Source	Invited Manuscript
All Author List	Rolf Gebhardt and Madlen Matz-Soja
Funding Agency and Grant Number	Funding Agency Grant Number Bundesministerium für Forschung und Technologie (BMBF) in the framework of the Systems Biology initiative “Virtual Liver Network” 0315735
Corresponding Author	Rolf Gebhardt, PhD, Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Johannissallee 30, 04103 Leipzig, Germany. rgebhardt@medizin.uni-leipzig.de
Key Words	Homeostasis; Liver; Metabolic zonation; Metabolism; Morphogen signalling; Optimization; Pathology; Regulatory network; Sinusoid; Systems biology
Core Tip	Liver metabolism comprises an immense spectrum of interrelated anabolic and catabolic functions which are performed simultaneously without wasting energy. To cope with this challenge, liver parenchyma shows a considerable heterogeneity and functional plasticity known as metabolic zonation. This review summarizes fascinating technical achievements in this field, covers recent progress in characterizing and visualizing zonation, and outlines an emerging network of master regulators that ensures proper maintenance of homeostasis and energetic optimization of liver function. Finally, an outlook is given on how disturbance of liver zonation and its regulation may impact on liver pathology and the development of metabolic diseases.
Publish Date	2014-07-14 17:39
Citation	Gebhardt R, Matz-Soja M. Liver zonation: Novel aspects of its regulation and its impact on homeostasis. World J Gastroenterol 2014; 20(26): 8491-8504
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8491.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8491

Full Article (PDF)	WJG-20-8491.pdf
Full Article (Word)	WJG-20-8491.doc
Manuscript File	6846-Review.doc
Answering Reviewers	6846-Answering reviewer.pdf
Copyright License Agreement	6846-Copyright assignement.pdf
Non-Native Speakers of English Editing Certificate	6846-Language certificate.pdf
Peer-review Report	6846-Peer review(s).pdf
Scientific Editor Work List	6846-Scientific editor work list.doc