Publication Name	World Journal of Gastroenterology
Manuscript ID	6855
Country	Taiwan

Received	2013-10-29 15:41
Peer-Review Started	2013-10-30 20:22
To Make the First Decision	2013-11-13 14:35
Return for Revision	2013-11-14 12:05
Revised	2013-12-07 00:21
Second Decision	2014-01-05 15:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-05 15:11
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-22 09:46
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Cyr61/CTGF/Nov family proteins in gastric carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Tsu-Yao Cheng, Ming-Shiang Wu, Kuo-Tai Hua, Min-Liang Kuo and Ming-Tsan Lin
Funding Agency and Grant Number
Corresponding Author	Ming-Tsan Lin, MD, PhD, Department of Surgery, National Taiwan University Hospital, No. 7 ChungShan South Road, Taipei 100, Taiwan. linmt@ntu.edu.tw
Key Words	Cyr61/CTGF/Nov proteins; Cysteine-rich angiogenic inducer 61; Connective tissue growth factor; Nephroblastoma over-expressed; Gastric cancer; Gastric carcinogenesis
Core Tip	Cyr61/CTGF/Nov (CCN) proteins are matricellular proteins responsible for many physiological and pathological processes, including carcinogenesis. The prototypical CCN family protein is composed of an N-terminal secretory signal peptide and four structural modules. Several truncated variants participate in the carcinogenesis of gastrointestinal tract cancers. The role of CCNs in carcinogenesis is tumor-type and context-dependent. The evidence suggests that CCN family proteins play important roles in gastric cancer (GC) carcinogenic processes. Recent CCN targeting agents, including monoclonal antibodies, antisense oligonucleotides and RNA interference compounds, may be helpful in future GC therapeutics.
Publish Date	2014-03-12 11:24
Citation	Cheng TY, Wu MS, Hua KT, Kuo ML, Lin MT. Cyr61/CTGF/Nov family proteins in gastric carcinogenesis. World J Gastroenterol 2014; 20(7): 1694-1700
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1694.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1694

Full Article (PDF)	WJG-20-1694.pdf
Full Article (Word)	WJG-20-1694.doc
Manuscript File	6855-Review.doc
Answering Reviewers	6855-Answering reviewers.pdf
Copyright License Agreement	6855-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	6855-Language certificate.pdf
Peer-review Report	6855-Peer review(s).pdf
Scientific Editor Work List	6855-Scientific editor work list.doc