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9/1/2014 10:11:00 AM | Browse: 462 | Download: 492
Publication Name World Journal of Critical Care Medicine
Manuscript ID 6885
Country of Manuscript Source United States
Received
2013-10-29 18:45
Peer-Review Started
2013-10-30 15:30
To Make the First Decision
2013-12-25 17:59
Return for Revision
2013-12-30 16:19
Revised
2014-01-21 23:48
Second Decision
2014-03-04 10:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-04 10:31
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-08 20:21
Publish the Manuscript Online
2014-05-20 21:40
ISSN 2220-3141(online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Medicine, Research and Experimental
Manuscript type Review
Article Title Metabolic theory of septic shock
Manuscript Source Invited Manuscript
All Author List Jay Pravda
Funding Agency and Grant Number
Corresponding author Jay Pravda, MD, MPH, Inflammatory Disease Research Centre, West Palm Beach, P.O. Box 32632, FL 33420, United States. jaypravda@yahoo.com
Keywords Septic shock; Hydrogen peroxide; Hypermetabolic; Sepsis; Systemic inflammatory response syndrome
Core Tip For decades septic shock has been attributed to an over-active immune response. However, immune modulation has failed to reduce mortality, casting doubt on a direct causal role for the immune response in the development of septic shock. A closer look suggests that septic shock is the result of a generalized build-up of hydrogen peroxide, a toxic cellular by-product generated as a consequence of the hypermetabolic state that accompanies a systemic immune response. This finding points to the systemic accumulation of hydrogen peroxide as a significant risk factor for the development of septic and non-septic shock syndromes.
Publish Date 2014-05-20 21:40
Citation Pravda J. Metabolic theory of septic shock. World J Crit Care Med 2014; 3(2): 45-54
Url http://www.wjgnet.com/2220-3141/full/v3/i2/45.htm
DOI http://dx.doi.org/10.5492/wjccm.v3.i2.45
Full Article (PDF) WJCCM-3-45.pdf
Full Article (Word) WJCCM-3-45.doc
Manuscript File 6885-Review.docx
Answering Reviewers 6885-Answering reviewers.pdf
Copyright License Agreement 6885-Copyright assignment.pdf
Peer-review Report 6885-Peer review(s).pdf
Scientific Editor Work List 6885-Scientific editor work list.doc