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11/24/2021 9:54:22 AM | Browse: 16 | Download: 9
Publication Name World Journal of Hepatology
Manuscript ID 68985
Country/Territory United Kingdom
Received
2021-06-11 09:04
Peer-Review Started
2021-06-11 09:09
To Make the First Decision
Return for Revision
2021-07-06 01:49
Revised
2021-07-19 07:57
Second Decision
2021-09-14 03:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-17 02:01
Articles in Press
2021-09-17 02:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-19 00:35
Publish the Manuscript Online
2021-11-24 09:54
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Minireviews
Article Title Cystic fibrosis associated liver disease in children
Manuscript Source Invited Manuscript
All Author List Joseph J Valamparampil and Girish L Gupte
ORCID
Author(s) ORCID Number
Joseph J Valamparampil http://orcid.org/0000-0002-8114-2523
Girish L Gupte http://orcid.org/0000-0002-9026-1583
Funding Agency and Grant Number
Corresponding Author Girish L Gupte, MD, Consultant Physician-Scientist, Liver Unit, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham B4 6NH, United Kingdom. girishgupte@nhs.net
Key Words Cystic fibrosis liver disease; Portal hypertension; Cirrhosis; Liver transplantation; Cystic fibrosis transmembrane conductance regulator modulators; Distal intestinal obstructive syndrome
Core Tip Cystic fibrosis liver disease is caused by abnormal cholangiocyte function, altered biliary secretion and abnormal innate immune response with abnormal response to endotoxins. Cystic fibrosis liver disease can present with a wide variety of clinical features from a heterogenous liver on ultrasound, to life threatening gastrointestinal bleeds secondary to portal hypertension. Novel treatment strategies directly targeting the ion channel abnormality-cystic fibrosis transmembrane conductance regulator modulators are available and has significantly improved the clinical status and life expectancy of the cystic fibrosis patients.
Publish Date 2021-11-24 09:54
Citation Valamparampil JJ, Gupte GL. Cystic fibrosis associated liver disease in children. World J Hepatol 2021; 13(11): 1727-1742
URL https://www.wjgnet.com/1948-5182/full/v13/i11/1727.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i11.1727
Full Article (PDF) WJH-13-1727.pdf
Full Article (Word) WJH-13-1727.docx
Manuscript File 68985_Auto_Edited.docx
Answering Reviewers 68985-Answering reviewers.pdf
Audio Core Tip 68985-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 68985-Conflict-of-interest statement.pdf
Copyright License Agreement 68985-Copyright license agreement.pdf
Peer-review Report 68985-Peer-review(s).pdf
Scientific Editor Work List 68985-Scientific editor work list.pdf