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10/7/2014 5:32:00 PM | Browse: 684 | Download: 504
Publication Name World Journal of Gastroenterology
Manuscript ID 6916
Country/Territory China
Received
2013-10-29 21:57
Peer-Review Started
2013-10-31 13:27
To Make the First Decision
2014-01-09 13:59
Return for Revision
2014-01-11 20:48
Revised
2014-03-10 15:18
Second Decision
2014-05-29 20:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-29 20:48
Articles in Press
2014-05-29 21:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-06-06 15:21
Typeset the Manuscript
2014-09-09 09:35
Publish the Manuscript Online
2014-10-07 17:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome
Manuscript Source Invited Manuscript
All Author List Xiu-Fang Cui, Wei-Mei Zhou, Yan Yang, Jun Zhou, Xue-Liang Li, Lin Lin and Hong-Jie Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81270469
Key Medical Personnel of Jiangsu Province RC2011063
Corresponding author Hong-Jie Zhang, MD, PhD, Professor, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. hjzhang06@163.com
Key Words Epidermal growth factor; Visceral hypersensitivity; Rat models; Serotonin transporter; Rat small intestinal epithelial cells; Intestinal epithelial cells; Irritable bowel syndrome
Core Tip Results of this study show that visceral hypersensitivity results in a decrease in the plasma and colon tissue levels of epidermal growth factor (EGF). Moreover, the EGF levels were positively correlated with serotonin transporter (SERT) levels. SERT gene expression and protein activity were upregulated in a dose- and time-dependent manner by EGF, and an inhibitor of the EGF receptor kinase blocked SERT gene expression and activity in an intestinal epithelial cell line. The data suggest that decreased EGF levels may contribute to the formation of visceral hypersensitivity through downregulation of SERT activity.
Publish Date 2014-10-07 17:32
Citation Cui XF, Zhou WM, Yang Y, Zhou J, Li XL, Lin L, Zhang HJ. Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome. World J Gastroenterol 2014; 20(37): 13521-13529
Url http://www.wjgnet.com/1007-9327/full/v20/i37/13521.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i37.13521
Full Article (PDF) WJG-20-13521.pdf
Full Article (Word) WJG-20-13521.doc
Manuscript File 6916-Review.docx
Answering Reviewers 6916-Answering reviewers.pdf
Copyright License Agreement 6916-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 6916-Language certificate.pdf
Peer-review Report 6916-Peer review(s).pdf
Scientific Misconduct Check 6916-CrossCheck.jpg
Scientific Editor Work List 6916-Scientific editor work list.pdf