Publication Name	World Journal of Psychiatry
Manuscript ID	69758
Country	Thailand

Received	2021-07-11 07:09
Peer-Review Started	2021-07-11 07:15
To Make the First Decision
Return for Revision	2021-10-04 00:50
Revised	2021-10-07 07:48
Second Decision	2022-04-21 02:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-04-26 05:34
Articles in Press	2022-04-26 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-04 22:28
Typeset the Manuscript	2022-04-28 08:03
Publish the Manuscript Online	2022-05-18 06:40

ISSN	2220-3206 (online)
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Category	Neurosciences
Manuscript Type	Opinion Review
Article Title	False dogmas in mood disorders research: Towards a nomothetic network approach
Manuscript Source	Invited Manuscript
All Author List	Michael HJ Maes and Drozdstoy Stoyanov
ORCID	Author(s) ORCID Number Michael HJ Maes http://orcid.org/0000-0002-2012-871X Drozdstoy Stoyanov http://orcid.org/0000-0002-9975-3680
Funding Agency and Grant Number	Funding Agency Grant Number Ratchadapiseksompotch Funds, Faculty of Medicine, Chulalongkorn University RA61/050
Corresponding Author	Michael HJ Maes, PhD, Professor, Department of Psychiatry, Chulalongkorn University, Rama IV, Bangkok 10330, Thailand. dr.michaelmaes@hotmail.com
Key Words	Nomothetic network psychiatry; Depression; Mood disorders; Affective disorders; Inflammation; Oxidative and nitrosative stress; Neuro-immune
Core Tip	We review the merits of machine learning-derived nomothetic network psychiatry (NNP) models of mood disorders. The NNP models of mood disorders show that major depressive disorder/bipolar disorder are not mind-brain or psycho-social but systemic medical disorders. The DSM/ICD taxonomies are counterproductive. A shared core, namely the reoccurrence of illness (ROI), underpins the intertwined recurrence of depressive and manic episodes and suicidal behaviors. Mood disorders should be ROI-defined. ROI mediates the effects of nitro-oxidative stress pathways and early lifetime trauma on the phenome of mood disorders. Severity of illness and treatment response should be delineated using NNP-derived causome, adverse outcome pathways, ROI and phenome scores.
Publish Date	2022-05-18 06:40
Citation	Maes MH, Stoyanov D. False dogmas in mood disorders research: Towards a nomothetic network approach. World J Psychiatry 2022; 12(5): 651-667
URL	https://www.wjgnet.com/2220-3206/full/v12/i5/651.htm
DOI	https://dx.doi.org/10.5498/wjp.v12.i5.651

Full Article (PDF)	WJP-12-651.pdf
Full Article (Word)	WJP-12-651.docx
Manuscript File	69758_Auto_Edited_LM.docx
Answering Reviewers	69758-Answering reviewers.pdf
Audio Core Tip	69758-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	69758-Conflict-of-interest statement.pdf
Copyright License Agreement	69758-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	69758-Grant application form(s).pdf
Peer-review Report	69758-Peer-review(s).pdf
Scientific Misconduct Check	69758-Bing-Wang JJ-2.png
Scientific Editor Work List	69758-Scientific editor work list.pdf