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9/11/2014 7:32:00 PM | Browse: 448 | Download: 401
Publication Name World Journal of Orthopedics
Manuscript ID 6977
Country/Territory Japan
Received
2013-10-31 11:14
Peer-Review Started
2013-11-01 09:32
To Make the First Decision
2013-12-02 11:42
Return for Revision
2013-12-03 21:20
Revised
2013-12-17 11:10
Second Decision
2014-03-04 10:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-04 10:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-03-11 15:47
Typeset the Manuscript
2014-04-14 11:06
Publish the Manuscript Online
2014-05-19 12:22
ISSN 2218-5836 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Review
Article Title Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis
Manuscript Source Invited Manuscript
All Author List Shigeru Kobayashi
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Science and Culture of Japan 25460719
Corresponding author Shigeru Kobayashi, MD, PhD, Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, and the Research and Education Program for Life Science, the University of Fukui, Shimoaizuki 23, Fukui 910-1193, Japan. kshigeru@u-fukui.ac.jp
Key Words Lumbar canal stenosis; Cauda equine; Nerve root; Prostaglandin E1; Blood flow
Core Tip The radicular symptoms associated with degenerative disease of the lumbar spine are reported to be attributable to a combination of mechanical nerve root compression and resultant circulatory disturbance. Disturbance of blood flow in the cauda equina and nerve roots is reported to play an important role in the mechanism of intermittent claudication in patients with lumbar canal stenosis. Prostaglandin E1 (PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis with intermittent claudication. However, investigations in the clinical setting have shown that lipo-PGE1 is effective in some patients but not in others, although the reason for this is unclear.
Publish Date 2014-05-19 12:22
Citation Kobayashi S. Pathophysiology, diagnosis and treatment of intermittent claudication in patients with lumbar canal stenosis. World J Orthop 2014; 5(2): 134-145
Url http://www.wjgnet.com/2218-5836/full/v5/i2/134.htm
DOI http://dx.doi.org/10.5312/wjo.v5.i2.134
Full Article (PDF) WJO-5-134.pdf
Full Article (Word) WJO-5-134.doc
Manuscript File 6977-Review.doc
Answering Reviewers 6977-Answering reviewers.pdf
Copyright License Agreement 6977-Copyright assignment.pdf
Peer-review Report 6977-Peer review(s).pdf
Scientific Editor Work List 6977-Scientific editor work list.doc