Publication Name	World Journal of Hepatology
Manuscript ID	6985
Country	Italy

Received	2013-10-31 12:00
Peer-Review Started	2013-11-01 09:46
To Make the First Decision	2013-12-02 11:42
Return for Revision	2013-12-03 21:14
Revised	2013-12-10 18:19
Second Decision	2014-02-18 12:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-18 12:33
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-12 21:53
Publish the Manuscript Online	2014-03-19 20:40

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Thyroid hormone analogues and derivatives: Actions in fatty liver
Manuscript Source	Invited Manuscript
All Author List	Maria Coppola, Daniela Glinni, Maria Moreno, Federica Cioffi, Elena Silvestri and Fernando Goglia
Funding Agency and Grant Number
Corresponding Author	Fernando Goglia, Professor of Physiology, Head of Department of Science and Technologies, University of Sannio, Via Port’Arsa 11, 82100 Benevento, Italy. goglia@unisannio.it
Key Words	Fatty liver; Thyroid hormones; Thyromimetics; 3; 5-diiodo-L-thyronine; Lipid metabolism
Core Tip	Fatty liver is associated with increased risk for the development of cirrhosis and hepatocellular carcinoma. Thyroid hormones have some potentially therapeutic actions by binding to specific nuclear receptors [thyroid hormone receptors (TR)] of which the TR? isoform is liver specific and a putative target for the treatment of dyslipidemia and fatty liver. This review provides (1) an overview of the action of T3 on lipid metabolism and (2) an update concerning the administration of TR? selective thyromimetics (GC-1 and MB07811), as well as of 3,5-diiodo-L-thyronine and its novel functional analogue TRC150094 in animal models of overweight and fatty liver.
Publish Date	2014-03-19 20:40
Citation	Coppola M, Glinni D, Moreno M, Cioffi F, Silvestri E, Goglia F. Thyroid hormone analogues and derivatives: Actions in fatty liver. World J Hepatol 2014; 6(3): 114-129
URL	http://www.wjgnet.com/1948-5182/full/v6/i3/114.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i3.114

Full Article (PDF)	WJH-6-114.pdf
Manuscript File	6985-Review.doc
Answering Reviewers	6985-Answering reviewers.pdf
Copyright License Agreement	6985-Copyright assignment.pdf
Peer-review Report	6985-Peer review(s).pdf
Scientific Editor Work List	6985-Scientific editor work list.doc