Publication Name	World Journal of Clinical Cases
Manuscript ID	70231
Country	Russia

Received	2021-07-27 06:14
Peer-Review Started	2021-07-27 06:20
To Make the First Decision
Return for Revision	2021-10-03 06:57
Revised	2021-10-17 07:53
Second Decision	2022-03-18 06:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-03-26 22:03
Articles in Press	2022-03-26 22:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-14 22:36
Typeset the Manuscript	2022-04-06 12:10
Publish the Manuscript Online	2022-04-21 11:35

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis
Manuscript Source	Invited Manuscript
All Author List	Dmitry Victorovich Garbuzenko
ORCID	Author(s) ORCID Number Dmitry Victorovich Garbuzenko http://orcid.org/0000-0001-9809-8015
Funding Agency and Grant Number
Corresponding Author	Dmitry Victorovich Garbuzenko, DSc, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, Box 12317, Chelyabinsk 454080, Russia. garb@inbox.ru
Key Words	Chronic liver disease; Liver fibrosis; Pathogenesis; Hepatic stellate cells; Activation; Pathophysiological mechanisms
Core Tip	This review focuses on the pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis. A better understanding of these pathophysiological mechanisms gave rise to drugs preventing liver fibrosis development and progression. In this respect, the disorder of the intracellular signaling regulation, epigenetic changes, and cellular stress response can be the target of an action aimed at hepatic stellate cells deactivation. This can be achieved by inducing their return to an inactive state, cellular aging, apoptosis, and/or clearance by immune cells, and may serve as potential antifibrotic therapy.
Publish Date	2022-04-21 11:35
Citation	Garbuzenko DV. Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis. World J Clin Cases 2022; 10(12): 3662-3676
URL	https://www.wjgnet.com/2307-8960/full/v10/i12/3662.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i12.3662

Full Article (PDF)	WJCC-10-3662.pdf
Full Article (Word)	WJCC-10-3662.docx
Manuscript File	70231_Auto_Edited-Ma YJ-FilipodiaCL.docx
Answering Reviewers	70231-Answering reviewers.pdf
Audio Core Tip	70231-Audio core tip.wav
Conflict-of-Interest Disclosure Form	70231-Conflict-of-interest statement.pdf
Copyright License Agreement	70231-Copyright license agreement.pdf
Peer-review Report	70231-Peer-review(s).pdf
Scientific Editor Work List	70231-Scientific editor work list.pdf