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Articles Published Processes
3/30/2022 3:20:26 PM | Browse: 319 | Download: 496
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Received |
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2021-12-07 21:02 |
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Peer-Review Started |
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2021-12-07 21:03 |
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To Make the First Decision |
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Return for Revision |
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2022-01-27 07:50 |
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Revised |
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2022-02-10 20:03 |
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Second Decision |
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2022-02-25 06:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-02-27 23:15 |
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Articles in Press |
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2022-02-27 23:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-03-23 11:38 |
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Publish the Manuscript Online |
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2022-03-30 15:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Locoregional therapies and their effects on the tumoral microenvironment of pancreatic ductal adenocarcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Thomas Lambin, Cyril Lafon, Robert Andrew Drainville, Mathieu Pioche and Frédéric Prat |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Labex DEVweCan (Université de Lyon) |
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| PCSI ITMO Cancer INSERM |
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| Corresponding Author |
Frédéric Prat, MD, Doctor, Service d’Endoscopie Digestive, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, 100 Bd du Général Leclerc, Clichy 92110, France. frederic.prat@aphp.fr |
| Key Words |
Pancreatic ductal adenocarcinoma; Tumoral microenvironment; Stroma; Hyperthermia; Radiation therapy; High-intensity focused ultrasound |
| Core Tip |
The prognosis of pancreatic ductal adenocarcinoma is poor, with a 5-year survival rate of approximately 8%. This is mainly due to an unfavorable tumoral microenvironment (tumor vasculature, stroma, and immune response). Locoregional therapies can alleviate some barriers to effective antitumoral treatment. This review explores the action of locoregional treatments on pancreatic cancer, with a specific focus on hyperthermia, radiation therapy, high-intensity focused ultrasound, and irreversible electroporation. After a description of the particularities of the tumoral microenvironment of pancreatic cancer, the effects of these treatments on the tumoral microenvironment and implications for future management of patients are discussed. |
| Publish Date |
2022-03-30 15:20 |
| Citation |
Lambin T, Lafon C, Drainville RA, Pioche M, Prat F. Locoregional therapies and their effects on the tumoral microenvironment of pancreatic ductal adenocarcinoma. World J Gastroenterol 2022; 28(13): 1288-1303 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i13/1288.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i13.1288 |
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