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8/26/2014 5:16:00 PM | Browse: 992 | Download: 848
Publication Name World Journal of Gastroenterology
Manuscript ID 7200
Country/Territory China
Received
2013-11-08 20:27
Peer-Review Started
2013-11-09 21:37
To Make the First Decision
2013-12-26 11:27
Return for Revision
2014-01-06 16:00
Revised
Second Decision
2014-03-19 13:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-19 15:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-04-17 12:03
Typeset the Manuscript
2014-05-14 09:07
Publish the Manuscript Online
2014-05-28 11:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer
Manuscript Source Invited Manuscript
All Author List Hu Zhang, You-Qing Zhu, Ya-Qiong Wu, Ping Zhang and Jian Qi
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81101868
Natural Science Foundation of Hubei Province of China 2011CDB505
Corresponding Author Jian Qi, PhD, MD, Department of Gastroenterology and Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. qiqidelizl@aliyun.com
Key Words Colorectal carcinoma; Secreted frizzled-related protein 2; Wnt inhibitory factor-1; Stool; Methylation
Core Tip Currently available approaches for the early detection of colorectal carcinoma (CRC) are suboptimal. The analysis of methylation markers in the stool as a non-invasive test is important for the early diagnosis of CRC. The epigenetic silencing of Wnt antagonist genes occurs in the early stages of CRC, and up to 90% of colorectal cancers result in the aberrant activation of Wnt signaling. In our study, we found that hypermethylated SFRP2 and WIF-1 genes in fecal DNA are novel and promising molecular biomarkers that have a great potential for the diagnosis of early CRC.
Publish Date 2014-05-28 11:45
Citation Zhang H, Zhu YQ, Wu YQ, Zhang P, Qi J. Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer. World J Gastroenterol 2014; 20(20): 6329-6335
URL http://www.wjgnet.com/1007-9327/full/v20/i20/6329.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i20.6329
Full Article (PDF) WJG-20-6329.pdf
Full Article (Word) WJG-20-6329.doc
Manuscript File 7200-Review.doc
Answering Reviewers 7200-Peer reviewer(s).pdf
Copyright License Agreement 7200-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 7200-Language certificate.pdf
Peer-review Report 7200-Peer reviewer(s).pdf
Scientific Editor Work List 7200-Scientific editor work list.doc