Publication Name	World Journal of Clinical Cases
Manuscript ID	72418
Country	Hungary

Received	2021-10-15 08:47
Peer-Review Started	2021-10-15 08:48
To Make the First Decision
Return for Revision	2021-12-12 14:52
Revised	2021-12-23 09:51
Second Decision	2022-05-18 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-22 23:31
Articles in Press	2022-05-22 23:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-13 09:00
Typeset the Manuscript	2022-06-16 08:30
Publish the Manuscript Online	2022-07-05 01:22

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Longitudinal changes in personalized platelet count metrics are good indicators of initial 3-year outcome in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Zoltan Herold, Magdolna Herold, Julia Lohinszky, A. Marcell Szasz, Magdolna Dank and Aniko Somogyi
ORCID	Author(s) ORCID Number Zoltan Herold http://orcid.org/0000-0001-5990-4889 Magdolna Herold http://orcid.org/0000-0002-1036-6343 Julia Lohinszky http://orcid.org/0000-0003-2241-4127 A. Marcell Szasz http://orcid.org/0000-0003-2739-4196 Magdolna Dank http://orcid.org/0000-0002-4694-3624 Aniko Somogyi http://orcid.org/0000-0003-0807-260X
Funding Agency and Grant Number	Funding Agency Grant Number Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (Hungary) UNKP-20-4-I New National Excellence Program
Corresponding Author	Zoltan Herold, MSc, PhD, Research Scientist, Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Tomo u. 25-29., Budapest 1083, Hungary. herold.zoltan@med.semmelweis-univ.hu
Key Words	Personalized platelet count; Lymphocyte-to-monocyte ratio; Neutrophil-to-lymphocyte ratio; Hemoglobin-to-platelet ratio; Platelet-to-lymphocyte ratio; Colorectal neoplasms
Core Tip	While the ability of various pre- and post-operative parameters of ratios from complete blood count to predict colorectal cancer (CRC) patient survival is known, their longitudinal changes with the course of the disease are not well documented. Temporal changes of complete blood count ratios of 835 CRC patients were investigated in this retrospective analysis. Two newly defined personalized platelet count metrics were introduced, and two distinct patterns were identified within the parameters examined. Most abnormal changes of the parameters occurred within the first 3 years after the diagnosis of CRC, which coincided with most of the CRC-related deaths.
Publish Date	2022-07-05 01:22
Citation	Herold Z, Herold M, Lohinszky J, Szasz AM, Dank M, Somogyi A. Longitudinal changes in personalized platelet count metrics are good indicators of initial 3-year outcome in colorectal cancer. World J Clin Cases 2022; 10(20): 6825-6844
URL	https://www.wjgnet.com/2307-8960/full/v10/i20/6825.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i20.6825

Full Article (PDF)	WJCC-10-6825.pdf
Full Article (Word)	WJCC-10-6825.docx
Manuscript File	72418_Auto_Edited-YXX-Wang TQ-LS.docx
Answering Reviewers	72418-Answering reviewers.pdf
Audio Core Tip	72418-Audio core tip.mp3
Biostatistics Review Certificate	72418-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	72418-Conflict-of-interest statement.pdf
Copyright License Agreement	72418-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72418-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	72418-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	72418-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	72418-Language certificate.pdf
Supplementary Material	72418-Supplementary material.pdf
Peer-review Report	72418-Peer-review(s).pdf
Scientific Misconduct Check	72418-Bing Xing YX-2.png
Scientific Editor Work List	72418-Scientific editor work list.pdf