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1/13/2022 11:55:40 AM | Browse: 22 | Download: 32
Publication Name World Journal of Gastroenterology
Manuscript ID 73265
Country/Territory United States
Received
2021-11-15 21:02
Peer-Review Started
2021-11-15 21:04
To Make the First Decision
Return for Revision
2021-11-22 03:28
Revised
2021-12-02 05:42
Second Decision
2022-01-11 03:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-11 19:34
Articles in Press
2022-01-11 19:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-01-12 04:56
Publish the Manuscript Online
2022-01-13 11:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Frontier
Article Title Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs
Manuscript Source Invited Manuscript
All Author List Andrzej S Tarnawski and Amrita Ahluwalia
ORCID
Author(s) ORCID Number
Andrzej S Tarnawski http://orcid.org/0000-0002-6813-6698
Amrita Ahluwalia http://orcid.org/0000-0002-2064-5725
Funding Agency and Grant Number
Corresponding Author Amrita Ahluwalia, PhD, Research Scientist, Research Service, Veterans Administration Long Beach Healthcare System, 5901 E, Seventh Street, Long Beach, CA 90822, United States. amrita.ahluwalia@va.gov
Key Words Endothelial cells; Impaired endothelial function; Blood vessels; SARS-CoV-2; COVID-19; Cytokine storm
Core Tip The coronavirus disease 2019 (COVID-19) pandemic has enormous health care and economic impact on the entire world - infecting more than 250 million people in 213 countries and territories, causing death of more than 5 million (as of November 1, 2021). We comment here on some outstanding papers on COVID-19 published in World Journal of Gastroenterology and reviewed the important role of endothelium and blood vessels in COVID-19 infection. Endothelial cells and blood vessels are both the targets and a conduit for the spread of severe acute respiratory syndrome coronavirus 2 and play a critical role in COVID-19-induced tissue injury and dissemination to various organs. Pre-existing endothelial impaired function could make endothelial cells more sensitive to COVID-19 or at least COVID-19-induced impairment might be synergistic with pre-existing impairment. That could be one contributing factor explaining why older or diabetic patients have more severe responses to infection, since these conditions are already impacted impaired endothelial function.
Publish Date 2022-01-13 11:55
Citation Tarnawski AS, Ahluwalia A. Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs. World J Gastroenterol 2022; 28(3): 275-289
URL https://www.wjgnet.com/1007-9327/full/v28/i3/275.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i3.275
Full Article (PDF) WJG-28-275.pdf
Full Article (Word) WJG-28-275.docx
Manuscript File 73265_Auto_Edited-V1.docx
Answering Reviewers 73265-Answering reviewers.pdf
Audio Core Tip 73265-Author core tip.m4a
Conflict-of-Interest Disclosure Form 73265-Conflict-of-interest statement.pdf
Copyright License Agreement 73265-Copyright license agreement.pdf
Peer-review Report 73265-Peer-review(s).pdf
Scientific Misconduct Check 73265-Bing-Wu YXJ-2.png
Scientific Editor Work List 73265-Scientific editor work list.pdf