Publication Name	World Journal of Gastroenterology
Manuscript ID	7366
Country	Germany

Received	2013-11-15 15:05
Peer-Review Started	2013-11-18 10:02
To Make the First Decision	2013-12-26 10:44
Return for Revision	2013-12-26 17:24
Revised	2014-01-05 02:43
Second Decision	2014-04-23 09:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-23 10:08
Articles in Press	2014-05-23 10:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-11 17:10
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Retrospective Study
Article Title	Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection
Manuscript Source	Invited Manuscript
All Author List
Funding Agency and Grant Number	Funding Agency Grant Number BMBF 0315905D (In part)
Corresponding Author	Prof. Dr. med. Dres. h. c. Peter Malfertheiner and Dr. med. Michael Selgrad Department of Gastroenterology, Hepatology and Infectious Diseases Otto-von-Guericke-University of Magdeburg Leipziger Str. 44 D-39120 Magdeburg Tel: 0049 391 6713100 Fax: 0049 391 6713105
Key Words	Helicobacter pylori treatment; antibiotic susceptibility; heteroresistance
Core Tip	In our study, we carefully assessed whether antibiotic resistance for commonly used antibiotics for H. pylori infection varies between the antrum and corpus of the stomach. Interestingly, discordant antibiotic susceptibility between antrum and corpus isolates accounted for 15.2% of the patients. DNA fingerprinting analysis revealed no substantial differences among DNA patterns between antrum and corpus isolates in the majority of patients suggesting an infection with a single H. pylori strain. In our opinion, different antibiotic susceptibility between antrum and corpus biopsies represents a possible explanation for treatment failure and resistant H. pylori strains may be missed if just one biopsy is taken from the stomach for H. pylori susceptibility testing. Those findings are in our opinion of great clinical interest.
Publish Date	2014-11-20 20:51
Citation	Selgrad M, Tammer I, Langner C, Bornschein J, Meißle J, Kandulski A, Varbanova M, Wex T, Schlüter D, Malfertheiner P. Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection. World J Gastroenterol 2014; 20(43): 16245-16251
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16245.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16245

Full Article (PDF)	WJG-20-16245.pdf
Full Article (Word)	WJG-20-16245.doc
Manuscript File	7366-Review.doc
Answering Reviewers	7366-Answering reviewers.pdf
Copyright License Agreement	7366-Copyright assignment.pdf
Peer-review Report	7366-Peer reviews.pdf
Scientific Editor Work List	7366-Scientific editor work list.doc