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8/3/2022 7:54:39 AM | Browse: 13 | Download: 33
Publication Name World Journal of Gastroenterology
Manuscript ID 73801
Country/Territory China
2021-12-04 06:17
Peer-Review Started
2021-12-04 06:20
To Make the First Decision
Return for Revision
2022-04-16 21:35
2022-04-28 06:18
Second Decision
2022-07-04 03:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-06 03:16
Articles in Press
2022-07-06 03:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-27 02:38
Publish the Manuscript Online
2022-08-03 07:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1
Manuscript Source Unsolicited Manuscript
All Author List Dong Chen, Miao-Miao Lu, Jin-Hai Wang, Yue Ren, Ling-Ling Xu, Wei-Xin Cheng, Sai-Sai Wang, Xiao-Lin Li, Xiao-Fei Cheng, Jian-Guo Gao, Farhin Shaheed Kalyani and Xi Jin
Author(s) ORCID Number
Dong Chen http://orcid.org/0000-0003-3892-9248
Miao-Miao Lu http://orcid.org/0000-0002-9328-8239
Jin-Hai Wang http://orcid.org/0000-0002-4640-7661
Yue Ren http://orcid.org/0000-0001-9071-2738
Ling-Ling Xu http://orcid.org/0000-0002-6668-3057
Wei-Xin Cheng http://orcid.org/0000-0003-1764-0779
Sai-Sai Wang http://orcid.org/0000-0002-5436-5385
Xiao-Lin Li http://orcid.org/0000-0003-3682-3237
Xiao-Fei Cheng http://orcid.org/0000-0003-3336-0996
Jian-Guo Gao http://orcid.org/0000-0002-9414-5395
Farhin Shaheed Kalyani http://orcid.org/0000-0001-8276-8125
Xi Jin http://orcid.org/0000-0001-9985-3035
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81770574
Natural Science Foundation of Zhejiang Province LZ21H030002, LY21H030005
Corresponding Author Xi Jin, MD, PhD, Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, NO.79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn
Key Words Metastasis-associated lung adenocarcinoma transcript; Crohn’s disease; miR-15a-5p; Mesenteric adipose tissue; Obesity; Colitis; Inflammatory bowel disease
Core Tip A higher visceral adipose tissue ratio has been associated with increased disease activity in patients with Crohn’s disease. However, the mechanisms underlying this effect remain unclear. Our study indicates that a high-fat diet increases the mesenteric adipose tissue content and aggravates colitis in mice. Mesenteric adipose tissue-derived exosome long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 can be absorbed by the colon, leading to the activation of the endoplasmic reticulum stress pathway by targeting the miR-15a-5p/activating transcription factor 6 axis to aggravate colitis.
Publish Date 2022-08-03 07:54
Citation Chen D, Lu MM, Wang JH, Ren Y, Xu LL, Cheng WX, Wang SS, Li XL, Cheng XF, Gao JG, Kalyani FS, Jin X. High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1. World J Gastroenterol 2022; 28(29): 3838-3853
URL https://www.wjgnet.com/1007-9327/full/v28/i29/3838.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i29.3838
Full Article (PDF) WJG-28-3838.pdf
Full Article (Word) WJG-28-3838.docx
Manuscript File 73801_Auto_Edited-LS.docx
Answering Reviewers 73801-Answering reviewers.pdf
Audio Core Tip 73801-Audio core tip.mp3
Biostatistics Review Certificate 73801-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 73801-Conflict-of-interest statement.pdf
Copyright License Agreement 73801-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 73801-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 73801-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 73801-Language certificate.pdf
Supplementary Material 73801-Supplementary material.pdf
Peer-review Report 73801-Peer-review(s).pdf
Scientific Misconduct Check 73801-Bing-Chen YL-2.png
Scientific Editor Work List 73801-Scientific editor work list.pdf