| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong Chen, Miao-Miao Lu, Jin-Hai Wang, Yue Ren, Ling-Ling Xu, Wei-Xin Cheng, Sai-Sai Wang, Xiao-Lin Li, Xiao-Fei Cheng, Jian-Guo Gao, Farhin Shaheed Kalyani and Xi Jin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81770574 |
| Natural Science Foundation of Zhejiang Province |
LZ21H030002, LY21H030005 |
|
| Corresponding Author |
Xi Jin, MD, PhD, Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, NO.79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn |
| Key Words |
Metastasis-associated lung adenocarcinoma transcript; Crohn’s disease; miR-15a-5p; Mesenteric adipose tissue; Obesity; Colitis; Inflammatory bowel disease |
| Core Tip |
A higher visceral adipose tissue ratio has been associated with increased disease activity in patients with Crohn’s disease. However, the mechanisms underlying this effect remain unclear. Our study indicates that a high-fat diet increases the mesenteric adipose tissue content and aggravates colitis in mice. Mesenteric adipose tissue-derived exosome long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 can be absorbed by the colon, leading to the activation of the endoplasmic reticulum stress pathway by targeting the miR-15a-5p/activating transcription factor 6 axis to aggravate colitis. |
| Publish Date |
2022-08-03 07:54 |
| Citation |
Chen D, Lu MM, Wang JH, Ren Y, Xu LL, Cheng WX, Wang SS, Li XL, Cheng XF, Gao JG, Kalyani FS, Jin X. High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1. World J Gastroenterol 2022; 28(29): 3838-3853 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i29/3838.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i29.3838 |
