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6/22/2022 8:29:42 AM | Browse: 28 | Download: 29
Publication Name World Journal of Clinical Oncology
Manuscript ID 74097
Country/Territory Argentina
2021-12-27 11:28
Peer-Review Started
2021-12-27 11:29
To Make the First Decision
Return for Revision
2022-02-15 00:08
2022-02-24 20:14
Second Decision
2022-04-19 02:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-04-26 18:30
Articles in Press
2022-04-26 18:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-05-24 09:32
Typeset the Manuscript
2022-06-14 06:20
Publish the Manuscript Online
2022-06-22 08:29
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells
Manuscript Source Invited Manuscript
All Author List Alejandro Español, Yamila Sanchez, Agustina Salem, Jaqueline Obregon and Maria Elena Sales
Author(s) ORCID Number
Alejandro Español http://orcid.org/0000-0001-8222-4259
Yamila Sanchez http://orcid.org/0000-0003-0554-0068
Agustina Salem http://orcid.org/0000-0002-9190-0906
Jaqueline Obregon http://orcid.org/0000-0002-1728-2732
Maria Elena Sales http://orcid.org/0000-0001-5086-0007
Funding Agency and Grant Number
Funding Agency Grant Number
University of Buenos Aires (UBA) UBACYT 2018-2022 20020170100227
National Research Council (CONICET) PIP 2015-2017 2015-0239
National Agency for Scientific and Technological Promotion (ANPCyT) PICT 2015-2017 2015-2396
Corresponding Author Alejandro Español, PhD, Research Scientist, Laboratory of Immunopharmacology and Tumor Biology, CEFYBO CONICET University of Buenos Aires, Paraguay 2155 16th Floor, Buenos Aires C1121ABG, Argentina. aespan_1999@yahoo.com
Key Words Breast cancer; Paclitaxel; Nicotinic acetylcholine receptors; Drug therapy; Signal transduction; Drug transporter
Core Tip Smokers with lung tumors are more likely to generate resistance to chemotherapy than non-smokers. However, little is known about the effect of nicotinic activation during the treatment of breast cancer, a cancer which arises close to the lung. In triple negative human breast cells, nicotine reduces the chemotherapeutic effect of paclitaxel through the participation of several kinases, as well as by modulating ATP “binding cassette” G2 drug transporter expression and inducing resistance to treatment. These results indicate that nicotinic acetylcholine receptors are a new possible target in antitumor therapy for this subtype of breast cancer.
Publish Date 2022-06-22 08:29
Citation Español A, Sanchez Y, Salem A, Obregon J, Sales ME. Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells. World J Clin Oncol 2022; 13(6): 505-519
URL https://www.wjgnet.com/2218-4333/full/v13/i6/505.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i6.505
Full Article (PDF) WJCO-13-505.pdf
Full Article (Word) WJCO-13-505.docx
Manuscript File 74097_Auto_Edited_LM-Language editing-Webster J-Clear.docx
Answering Reviewers 74097-Answering reviewers.pdf
Audio Core Tip 74097-Audio core tip.mp3
Biostatistics Review Certificate 74097-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 74097-Conflict-of-interest statement.pdf
Copyright License Agreement 74097-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 74097-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 74097-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 74097-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 74097-Language certificate.pdf
Peer-review Report 74097-Peer-review(s).pdf
Scientific Misconduct Check 74097-Bing-Gao CC-2.png
Scientific Editor Work List 74097-Scientific editor work list.pdf