Publication Name	World Journal of Orthopedics
Manuscript ID	7413
Country	Italy

Received	2013-11-17 07:44
Peer-Review Started	2013-11-18 15:48
To Make the First Decision	2013-12-10 14:31
Return for Revision	2013-12-17 16:16
Revised	2013-12-31 01:03
Second Decision	2014-05-29 15:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 15:58
Articles in Press	2014-05-29 15:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-01 09:05
Publish the Manuscript Online	2014-07-19 23:48

ISSN	2218-5836 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Topic Highlights
Article Title	Bone anabolics in osteoporosis: Actuality and perspectives
Manuscript Source	Invited Manuscript
All Author List	Andrea Montagnani
Funding Agency and Grant Number
Corresponding Author	Andrea Montagnani, MD, PhD, Metabolic Bone Diseases Area, Department of Internal Medicine, Misericordia Hospital, Via Senese, 169, 58100 Grosseto, Italy. montagnaniand@gmail.com
Key Words	Anabolic therapy; Bone mass; Bone fracture; Osteoporosis
Core Tip	The study of agents active on bone formation is the main objective in the treatment of severe osteoporosis. rhparathyroid hormone (rhPTH) decreases vertebral, but not nonvertebral, fractures. On the contrary, antagonists of Wnt-inhibitors, that exert their effects mostly through a bone remodeling-independent mechanism, open new perspectives to improve not only trabecular bone but also cortical bone, with potential positive effect also on nonvertebral fractures incidence. The perspective in osteoporosis treatment should be more effective and better tolerated therapies aimed at minimizing individually fractures risk.
Publish Date	2014-07-19 23:48
Citation	Montagnani A. Bone anabolics in osteoporosis: Actuality and perspectives. World J Orthop 2014; 5(3): 247-254
URL	http://www.wjgnet.com/2218-5836/full/v5/i3/247.htm
DOI	http://dx.doi.org/10.5312/wjo.v5.i3.247

Full Article (PDF)	WJO-5-247.pdf
Full Article (Word)	WJO-5-247.doc
Manuscript File	7413-Review.docx
Answering Reviewers	7413-Answering reviewers.pdf
Copyright License Agreement	7413-Copyright assignment.pdf
Peer-review Report	7413-Peer review(s).pdf
Scientific Misconduct Check	7413-CrossCheck.jpg
Scientific Editor Work List	7413-Scientific editor work list.pdf