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9/18/2014 7:49:00 PM | Browse: 477 | Download: 395
Publication Name World Journal of Gastroenterology
Manuscript ID 7470
Country/Territory United States
2013-11-20 15:23
Peer-Review Started
2013-11-20 19:40
To Make the First Decision
2014-03-28 18:32
Return for Revision
2014-03-29 12:05
2014-05-15 00:00
Second Decision
2014-06-13 11:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-13 12:47
Articles in Press
2014-06-13 13:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-01 09:44
Publish the Manuscript Online
2014-09-18 19:50
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Randomized Controlled Trial
Article Title Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic
Manuscript Source Invited Manuscript
All Author List Telma Noguera, Robert Wotring, Chris R Melville, Kara Hargraves, Jochen Kumm and John M Morton
Funding Agency and Grant Number
Corresponding author John M Morton, MD, MPH, Chief of Bariatric and Minimally Invasive Surgery, Stanford School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305, United States. research@greenteaspoon.com
Keywords Prebiotic; Gastroenteritis; Diarrhea; Rotavirus; Infant Mortality; Dehydration; Heartburn; Polyphenol; Aliva; Greenteaspoon
Core Tip The global standard of care for treating acute gastroenteritis in children is 5-10 d of oral rehydration therapy, which saves lives and may reduce the duration of the illness by 20%. In this double-blind, placebo-controlled clinical study, 60% of subjects treated with a novel polyphenol-based prebiotic experienced their last unformed stool within 2 h vs 25% of the placebo treated subjects, and 89% within 24 h vs 38% of the placebo treated group. This represents a potentially extraordinary advance in the clinical management of acute gastroenteritis. If these results can be confirmed in additional studies with different populations, this treatment should become the new global standard of care.
Publish Date 2014-09-18 19:50
Citation Noguera T, Wotring R, Melville CR, Hargraves K, Kumm J, Morton JM. Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic. World J Gastroenterol 2014; 20(34): 12301-12307
Url http://www.wjgnet.com/1007-9327/full/v20/i34/12301.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i34.12301
Full Article (PDF) WJG-20-12301.pdf
Full Article (Word) WJG-20-12301.doc
Manuscript File 7470-Review.docx
Answering Reviewers 7470-Answering reviewers.pdf
Copyright License Agreement 7470-Copyright assignment.pdf
Peer-review Report 7470-Peer review.pdf
Scientific Misconduct Check 7470-CorssCheck.jpg
Scientific Editor Work List 7470-Scientific editor work list.pdf