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8/26/2014 2:23:00 PM | Browse: 916 | Download: 949
Publication Name World Journal of Hepatology
Manuscript ID 7480
Country/Territory Greece
Received
2013-11-21 10:29
Peer-Review Started
2013-11-21 18:57
To Make the First Decision
2013-12-25 18:13
Return for Revision
2013-12-27 20:43
Revised
2014-01-20 14:02
Second Decision
2014-03-04 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-04 10:24
Articles in Press
2014-05-27 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-18 20:05
Publish the Manuscript Online
2014-05-27 11:34
ISSN 1948-5182 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anesthesiology
Manuscript Type Autobiography
Article Title CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia
Manuscript Source Invited Manuscript
All Author List Chrysanthi Batistaki, George Michalopoulos, Paraskevi Matsota, Tzortzis Nomikos, Konstantinos Kalimeris, Maria Riga, Maria Nakou and Georgia Kostopanagiotou
Funding Agency and Grant Number
Corresponding Author Chrysanthi Batistaki, Assistant Professor of Anesthesiology, 2nd Department of Anesthesiology, School of Medicine, University of Athens, “Attikon Hospital”, 1 Rimini str, 12462 Athens, Greece. chrysabatistaki@yahoo.gr
Key Words Drug-induced-liver injury; Desflurane; Anesthesia; Hepatotoxicity; CYP2E1 IgG4
Core Tip Several case reports of hepatotoxicity following anesthesia with desflurane have been published in the literature, implicating cytochrome P450 2E1-IgG4 autoantibodies. This study investigates the possible changes in CYP2E1 IgG4 autoantibody levels and other biochemical markers of liver injury in 40 adult patients who received anesthesia with desflurane for elective surgery. Samples were obtained before and 96 h after exposure to desflurane, and no significant difference was observed in levels of CYP2E1 IgG4, a-glutamyl-S-transferase, aspartate aminotransferase, alanine aminotransferase, g-glutamyl-transpeptidase or alkaline phosphatase levels, regardless of patients’ previous exposure to volatile anesthetics.
Publish Date 2014-05-27 11:34
Citation Batistaki C, Michalopoulos G, Matsota P, Nomikos T, Kalimeris K, Riga M, Nakou M, Kostopanagiotou G. CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia. World J Hepatol 2014; 6(5): 340-346
URL http://www.wjgnet.com/1948-5182/full/v6/i5/340.htm
DOI http://dx.doi.org/10.4254/wjh.v6.i5.340
Full Article (PDF) WJH-6-340.pdf
Full Article (Word) WJH-6-340.doc
Manuscript File 7480-Review.doc
Answering Reviewers 7480-Answering reviewers.pdf
Copyright License Agreement 7480-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20131120180820.pdf
Non-Native Speakers of English Editing Certificate 7480-Language certificate.pdf
Peer-review Report 7480-Peer review(s).pdf
Scientific Editor Work List 7480-Scientific editor work list.doc