Publication Name	World Journal of Gastroenterology
Manuscript ID	74872
Country	China

Received	2022-01-09 16:06
Peer-Review Started	2022-01-09 16:08
To Make the First Decision
Return for Revision	2022-03-08 21:59
Revised	2022-04-02 15:27
Second Decision	2022-06-20 03:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-26 06:39
Articles in Press	2022-06-26 06:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-13 07:46
Publish the Manuscript Online	2022-07-27 02:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Gastric mucosal precancerous lesions in Helicobacter pylori-infected pediatric patients in central China: A single-center, retrospective investigation
Manuscript Source	Unsolicited Manuscript
All Author List	Miao Yu, Jing Ma, Xiao-Xia Song, Qiao-Qiao Shao, Xue-Chun Yu, Muhammad Noman Khan, Ya-Bin Qi, Ruo-Bing Hu, Pei-Ru Wei, Wei Xiao, Bai-Ling Jia, Yan-Bo Cheng, Ling-Fei Kong, Chuan-Liang Chen and Song-Ze Ding
ORCID	Author(s) ORCID Number Miao Yu http://orcid.org/0000-0002-3587-2760 Jing Ma http://orcid.org/0000-0003-1172-527X Xiao-Xia Song http://orcid.org/0000-0003-4633-9862 Qiao-Qiao Shao http://orcid.org/0000-0002-4900-9394 Xue-Chun Yu http://orcid.org/0000-0003-4425-6019 Muhammad Noman Khan http://orcid.org/0000-0003-4814-7768 Ya-Bin Qi http://orcid.org/0000-0002-7736-4043 Ruo-Bing Hu http://orcid.org/0000-0003-4735-1310 Pei-Ru Wei http://orcid.org/0000-0001-6306-590X Wei Xiao http://orcid.org/0000-0002-6814-9261 Bai-Ling Jia http://orcid.org/0000-0002-2920-2322 Yan-Bo Cheng http://orcid.org/0000-0003-3203-4603 Ling-Fei Kong http://orcid.org/0000-0003-1710-8344 Chuan-Liang Chen http://orcid.org/0000-0002-5566-7297 Song-Ze Ding http://orcid.org/0000-0002-4589-6942
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China U1604174 Henan Provincial Government-Health and Family Planning Commission 20170123 Henan Provincial Government-Health and Family Planning Commission SBGJ202002004 Henan Provincial Government-Health and Family Planning Commission Research Innovative Talents Project 51282
Corresponding Author	Song-Ze Ding, MD, PhD, Professor, Department of Gastroenterology and Hepatology, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, Henan Province, China. dingsongze@hotmail.com
Key Words	Children and adolescents; Inflammation; Precancerous lesions; Gastric cancer; Helicobacter pylori
Core Tip	Helicobacter pylori (H. pylori) infection induces gastric mucosal precancerous lesions mostly in adulthood. Whether these lesions can also occur in children and adolescents remains controversial. Our study showed that in a region in central China with a high prevalence of H. pylori and gastric cancer, the incidence of gastric mucosal precancerous lesions was 4.33% among H. pylori-infected children and adolescents, which is significantly higher than the non-infected pediatric patients. The precancerous lesions included atrophic gastritis, intestinal metaplasia, and dysplasia. These data provide an alarming alert and call for further investigation and intervention for this population group.
Publish Date	2022-07-27 02:48
Citation	Yu M, Ma J, Song XX, Shao QQ, Yu XC, Khan MN, Qi YB, Hu RB, Wei PR, Xiao W, Jia BL, Cheng YB, Kong LF, Chen CL, Ding SZ. Gastric mucosal precancerous lesions in Helicobacter pylori-infected pediatric patients in central China: A single-center, retrospective investigation. World J Gastroenterol 2022; 28(28): 3682-3694
URL	https://www.wjgnet.com/1007-9327/full/v28/i28/3682.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i28.3682

Full Article (PDF)	WJG-28-3682.pdf
Full Article (Word)	WJG-28-3682.docx
Manuscript File	74872_Auto_Edited-LS.docx
Answering Reviewers	74872-Answering reviewers.pdf
Audio Core Tip	74872-Audio core tip.aac
Biostatistics Review Certificate	74872-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	74872-Conflict-of-interest statement.pdf
Copyright License Agreement	74872-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74872-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	74872-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	74872-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	74872-Language certificate.pdf
Peer-review Report	74872-Peer-review(s).pdf
Scientific Misconduct Check	74872-Bing-Yan JP-2.png
Scientific Editor Work List	74872-Scientific editor work list.pdf
CrossCheck Report	74872-CrossCheck report.pdf