| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
HP0953 - hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nancy K Arteaga-Resendiz, Gerardo E Rodea, Rosa María Ribas-Aparicio, Alma L Olivares-Cervantes, Juan Arturo Castelán-Vega, José de Jesús Olivares-Trejo, Sandra Mendoza-Elizalde, Edgar O López-Villegas, Christian Colín, Pamela Aguilar-Rodea, Alfonso Reyes-López, Marcela Salazar García and Norma Velázquez-Guadarrama |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Federal Funds |
HIM/2009/037. SSA851, HIM / 2014/012. SSA 1098 |
| the grant from Secretaría de Investigación y Posgrado |
SIP 20161878 |
| the Instituto Politécnico Nacional by Consejo Nacional de Ciencia y Tecnología |
CB-222180 |
|
| Corresponding Author |
Norma Velázquez-Guadarrama, PhD, Research Scientist, Laboratorio de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Dr. Márquez 162, Col. Doctores, Alcaldía Cuauhtémoc, Mexico City 06720, Mexico. normave@himfg.edu.mx |
| Key Words |
Hypothetical protein HP0953; Adherence; Helicobacter pylori; Glycocalyx; Virulence factor; Persistence |
| Core Tip |
The high prevalence and persistence of Helicobacter pylori infection and the diverse pathologies associated with it suggest that the virulence factors of this microorganism are varied. Moreover, its proteome contains 340 hypothetical proteins, so it is crucial to investigate them to elucidate the mechanisms of its virulence and survival. We studied the hypothetical protein HP0953, its location around infected cells, and the probable posttranslational modifications. Its similarity to an exotoxin suggests that HP0953 is a virulence factor. |
| Publish Date |
2022-08-03 07:54 |
| Citation |
Arteaga-Resendiz NK, Rodea GE, Ribas-Aparicio RM, Olivares-Cervantes AL, Castelán-Vega JA, Olivares-Trejo JJ, Mendoza-Elizalde S, López-Villegas EO, Colín C, Aguilar-Rodea P, Reyes-López A, Salazar García M, Velázquez-Guadarrama N. HP0953 - hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium. World J Gastroenterol 2022; 28(29): 3886-3902 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i29/3886.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i29.3886 |
