Publication Name	World Journal of Gastroenterology
Manuscript ID	75406
Country	United States

Received	2022-01-27 04:28
Peer-Review Started	2022-01-27 04:29
To Make the First Decision
Return for Revision	2022-04-10 21:28
Revised	2022-04-13 14:56
Second Decision	2022-08-30 03:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-31 20:03
Articles in Press	2022-08-31 20:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-08-18 10:38
Typeset the Manuscript	2022-09-02 01:55
Publish the Manuscript Online	2022-09-15 13:37

ISSN	1007-9327 (print) and 2219-2840 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Urotensin II level is elevated in inflammatory bowel disease patients
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Zhang and Guo-Xun Chen
ORCID	Author(s) ORCID Number Yan Zhang http://orcid.org/0000-0002-0620-5803 Guo-Xun Chen http://orcid.org/0000-0001-6226-4050
Funding Agency and Grant Number
Corresponding Author	Guo-Xun Chen, PhD, Associate Professor, Research Scientist, Department of Nutrition, The University of Tennessee, Room 229, Jessie Harris Building, 1512 West Cumberland Avenue, Knoxville, TE 37996, United States. gchen6@utk.edu
Key Words	Inflammatory bowel disease; Urotensin II; Inflammatory factors; High sensitivity C reactive peptide
Core Tip	An observational report showed that the level of urotensin II (U-II) in inflammatory bowel disease (IBD) patients was significantly increased compared with that in controls. The authors also reported that blood U-II level was positively correlated with high-sensitivity C-reactive protein, and severe endoscopic features of the disease. This study provides us with a new role of U-II in IBD, which warrants larger, multicenter clinical and basic studies to determine the mechanisms by which U-II triggers inflammatory responses and activates signaling pathways (EPK1/2, NF-κB and Rho/ROCK).
Publish Date	2022-09-15 13:37
Citation	Zhang Y, Chen GX. Elevation of Urotensin II level in patients with inflammatory bowel disease. World J Gastroenterol 2022; 28(35): 5230-5232
URL	https://www.wjgnet.com/1007-9327/full/v28/i35/5230.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i35.5230

Full Article (PDF)	WJG-28-5230.pdf
Full Article (Word)	WJG-28-5230.docx
Manuscript File	75406_Auto_Edited-YLC-Kerr C-LS.docx
Answering Reviewers	75406-Answering reviewers.pdf
Audio Core Tip	75406-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	75406-Conflict-of-interest statement.pdf
Copyright License Agreement	75406-Copyright license agreement.pdf
Peer-review Report	75406-Peer-review(s).pdf
Scientific Misconduct Check	75406-Bing-Chen YL-2.png
Scientific Editor Work List	75406-Scientific editor work list.pdf