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6/24/2022 9:00:24 AM | Browse: 198 | Download: 451
Publication Name World Journal of Clinical Cases
Manuscript ID 75509
Country/Territory China
Received
2022-02-01 13:52
Peer-Review Started
2022-02-01 13:53
To Make the First Decision
Return for Revision
2022-03-15 08:18
Revised
2022-03-21 05:24
Second Decision
2022-04-08 02:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-04-09 18:26
Articles in Press
2022-04-09 18:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-06-15 10:52
Publish the Manuscript Online
2022-06-24 09:00
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Intestinal mucosal barrier in functional constipation: Dose it change?
Manuscript Source Unsolicited Manuscript
All Author List Jun-Ke Wang, Wei Wei, Dong-Yan Zhao, Hui-Fen Wang, Yan-Li Zhang, Jie-Ping Lei and Shu-Kun Yao
ORCID
Author(s) ORCID Number
Jun-Ke Wang http://orcid.org/0000-0002-4690-9127
Wei Wei http://orcid.org/0000-0002-8388-0423
Dong-Yan Zhao http://orcid.org/0000-0002-7026-068X
Hui-Fen Wang http://orcid.org/0000-0002-0899-1473
Yan-Li Zhang http://orcid.org/0000-0003-4609-7330
Jie-Ping Lei http://orcid.org/0000-0002-2862-7249
Shu-Kun Yao http://orcid.org/0000-0002-8512-2589
Funding Agency and Grant Number
Corresponding Author Shu-Kun Yao, MD, PhD, Doctor, Professor, Graduate school, Peking Union Medical College and Chinese Academy of Medical Sciences, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China, Beijing 100730, China. shukunyao@126.com
Key Words Intestinal mucosal barrier; Functional constipation; Goblet cells; Intercellular junctions; Mucosal immunity; Gut permeability
Core Tip The present study investigated the intestinal mucosal barrier in functional constipation (FC) patients for the first time, including the mucus barrier, the intestinal epithelial barrier, the mucosal immune state and gut permeability. FC patients exhibited a significant increase in goblet cells and integral intercellular junctional complexes. There were no significant alterations in the localization and expression of occludin and zonula occludens-1 in FC patients. No significant increase in CD3+ intraepithelial lymphocytes, CD3+ lamina propria lymphocytes, serum D-lactic acid or zonulin levels was found in FC patients, which indicated no mucosal immune activation or increased gut permeability.
Publish Date 2022-06-24 09:00
Citation Wang JK, Wei W, Zhao DY, Wang HF, Zhang YL, Lei JP, Yao SK. Intestinal mucosal barrier in functional constipation: Dose it change? World J Clin Cases 2022; 10(19): 6385-6398
URL https://www.wjgnet.com/2307-8960/full/v10/i19/6385.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i19.6385
Full Article (PDF) WJCC-10-6385.pdf
Full Article (Word) WJCC-10-6385.docx
STROBE Statement 75509-STROBE-Statement-revision.pdf
Manuscript File 75509_Auto_Edited-LJH.docx
Answering Reviewers 75509-Answering reviewers.pdf
Audio Core Tip 75509-Audio core tip.mp3
Biostatistics Review Certificate 75509-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 75509-Conflict-of-interest statement.pdf
Copyright License Agreement 75509-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 75509-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 75509-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 75509-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 75509-Language certificate.pdf
Peer-review Report 75509-Peer-review(s).pdf
Scientific Misconduct Check 75509-Bing-Liu JH-2.jpg
Scientific Misconduct Check 75509-CrossCheck.jpg
Scientific Editor Work List 75509-Scientific editor work list.pdf