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8/26/2014 11:43:00 AM | Browse: 1001 | Download: 921
Publication Name World Journal of Gastroenterology
Manuscript ID 7555
Country/Territory Japan
Received
2013-12-10 16:20
Peer-Review Started
2013-12-10 17:07
To Make the First Decision
2014-01-09 16:15
Return for Revision
2014-01-17 08:40
Revised
2014-01-28 18:30
Second Decision
2014-03-05 14:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-05 14:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-16 10:53
Publish the Manuscript Online
2014-07-03 15:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Fibrogenesis in alcoholic liver disease
Manuscript Source Invited Manuscript
All Author List Hideki Fujii and Norifumi Kawada
Funding Agency and Grant Number
Funding Agency Grant Number
Japan Society for the Promotion of Science (JSPS) 25293177 (to Kawada N) (2013-2016)
JSPS 25461007 (to Fujii H) (2013-2016)
Corresponding Author Norifumi Kawada, MD, PhD, Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan. kawadanori@med.osaka-cu.ac.jp
Key Words Stellate cell; Kupffer cell; Steatohepatitis; Fibrosis; Cytokine; Oxidative stress
Core Tip Alcoholic liver disease (ALD) is a major cause of preventable morbidity and mortality worldwide. In ALD-associated fibrosis, hepatic stellate cells are the principal cell type responsible for extracellular matrix production. Although the mechanisms underlying ALD-associated fibrosis are largely similar to those observed in other chronic liver diseases, oxidative stress, abnormal methionine metabolism, hepatocyte apoptosis, and endotoxin lipopolysaccharides that activate Kupffer cells play unique roles in fibrogenesis in ALD. Recently, lipogenesis during the early stages of ALD has been implicated as a risk factor for progression of cirrhosis. Other critical factors include osteopontin, interleukin-1 signaling, and genetic polymorphisms.
Publish Date 2014-07-03 15:30
Citation Fujii H, Kawada N. Fibrogenesis in alcoholic liver disease. World J Gastroenterol 2014; 20(25): 8048-8054
URL http://www.wjgnet.com/1007-9327/full/v20/i25/8048.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i25.8048
Full Article (PDF) WJG-20-8048.pdf
Full Article (Word) WJG-20-8048.doc
Manuscript File 7555-Review.docx
Answering Reviewers 7555-Answering reviewers.pdf
Copyright License Agreement 7555-Copyright assignmentt.pdf
Peer-review Report 7555-Peer review(s).pdf
Scientific Editor Work List 7555-Scientific editor work list.doc