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6/24/2022 9:00:25 AM | Browse: 249 | Download: 423
Publication Name World Journal of Clinical Cases
Manuscript ID 75684
Country/Territory China
Received
2022-02-12 09:29
Peer-Review Started
2022-02-12 09:31
To Make the First Decision
Return for Revision
2022-03-25 00:36
Revised
2022-04-07 15:39
Second Decision
2022-04-29 03:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-04-30 07:35
Articles in Press
2022-04-30 07:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-05-25 06:17
Publish the Manuscript Online
2022-06-24 09:00
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Case Report
Article Title Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor non responses in an adult with a history of coronary revascularization: A case report
Manuscript Source Unsolicited Manuscript
All Author List Liu Yang, Yan-Yan Xiao, Liang Shao, Chang-Sheng Ouyang, Yao Hu, Bin Li, Li-Feng Lei and Hong Wang
ORCID
Author(s) ORCID Number
Liu Yang http://orcid.org/0000-0002-4272-7473
Yan-Yan Xiao http://orcid.org/0000-0002-3659-1223
Liang Shao http://orcid.org/0000-0003-2676-3332
Chang-Sheng Ouyang http://orcid.org/0000-0002-0232-5576
Yao Hu http://orcid.org/0000-0003-3173-8844
Bin Li http://orcid.org/0000-0003-2987-9787
Li-Feng Lei http://orcid.org/0000-0002-7601-2476
Hong Wang http://orcid.org/0000-0003-1505-4469
Funding Agency and Grant Number
Funding Agency Grant Number
Doctor Start-up fund of Jiangxi provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College 19-236
Corresponding Author Hong Wang, MD, Chief Physician, Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Donghu District, Nanchang 330006, Jiangxi Province, China. hongwangjx@21cn.com
Key Words Coronary artery disease; Familial hypercholesterolemia; Low-density lipoprotein receptor mutation; Non response; Proprotein convertase subtilisin/kexin type 9 inhibitor
Core Tip We report a male Chinese patient diagnosed with Familial hypercholesterolemia (FH) with a heterozygous mutation, 1448G>A (W483X), of the low-density lipoprotein receptor (LDLR). By reviewing the literature, we speculate that the mutation may affects LDLR metabolism or structure and may lead to that responded modestly after treatment with PCSK9 inhibitor (PCSK9i).
Publish Date 2022-06-24 09:00
Citation Yang L, Xiao YY, Shao L, Ouyang CS, Hu Y, Li B, Lei LF, Wang H. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor non responses in an adult with a history of coronary revascularization: A case report. World J Clin Cases 2022; 10(19): 6728-6735
URL https://www.wjgnet.com/2307-8960/full/v10/i19/6728.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i19.6728
Full Article (PDF) WJCC-10-6728.pdf
Full Article (Word) WJCC-10-6728.docx
CARE Checklist–2016 75684-CARE-Checklist–2016-revision.pdf
Manuscript File 75684_Auto_Edited.docx
Answering Reviewers 75684-Answering reviewers.pdf
Audio Core Tip 75684-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 75684-Conflict-of-interest statement.pdf
Copyright License Agreement 75684-Copyright-License-Agreement-revision.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 75684-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s) 75684-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 75684-Language certificate.pdf
Peer-review Report 75684-Peer-review(s).pdf
Scientific Misconduct Check 75684-Bing-Wang LL-2.png
Scientific Editor Work List 75684-Scientific editor work list.pdf