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9/9/2022 3:45:24 PM | Browse: 256 | Download: 607
Publication Name World Journal of Diabetes
Manuscript ID 76316
Country/Territory France
Received
2022-03-11 17:33
Peer-Review Started
2022-03-11 17:35
To Make the First Decision
Return for Revision
2022-04-25 22:15
Revised
2022-05-13 07:27
Second Decision
2022-08-18 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-22 19:16
Articles in Press
2022-08-22 19:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-08-04 17:17
Typeset the Manuscript
2022-09-04 11:00
Publish the Manuscript Online
2022-09-09 15:45
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Basic Study
Article Title Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation
Manuscript Source Invited Manuscript
All Author List Christian Carpéné, Kristiyan Stiliyanov Atanasov, Francisco Les and Josep Mercader Barcelo
ORCID
Author(s) ORCID Number
Christian Carpéné http://orcid.org/0000-0001-7765-6647
Kristiyan Stiliyanov Atanasov http://orcid.org/0000-0003-3202-9716
Francisco Les http://orcid.org/0000-0002-7972-7119
Josep Mercader Barcelo http://orcid.org/0000--0002-5293-2809
Funding Agency and Grant Number
Corresponding Author Christian Carpéné, PhD, Senior Researcher, Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1297, Université Paul Sabatier Toulouse III, CHU Rangueil, Bat L4, BP 84225, Toulouse 31432, France. christian.carpene@inserm.fr
Key Words Diabetes; Adipocytes; Amine oxidases; Insulin-like agents; Glucose transport; Polydipsia
Core Tip In adipocytes, benzylamine (Bza) is oxidized by amine oxidases and stimulates glucose uptake. Bza oral administration alleviates insulin-resistant diabetes in obese and diabetic mice. It was investigated whether Bza was also antihyperglycemic in insulin-deficient type 1 diabetes. To this aim, a 0.5% Bza drinking solution was given to streptozotocin-induced diabetic mice. Oral Bza did not recover hyperglycemia and reduced adiposity of lipoatrophic and diabetic mice. A minimal level of adiposity was required to support benzylamine oxidation and to improve glucose utilization. Thus, the antidiabetic properties of Bza in obese and diabetic models, do not apply for diabetes with severe lipoatrophy.
Publish Date 2022-09-09 15:45
Citation Carpéné C, Stiliyanov Atanasov K, Les F, Mercader Barcelo J. Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation. World J Diabetes 2022; 13(9): 752-764
URL https://www.wjgnet.com/1948-9358/full/v13/i9/752.htm
DOI https://dx.doi.org/10.4239/wjd.v13.i9.752
Full Article (PDF) WJD-13-752.pdf
Full Article (Word) WJD-13-752.docx
The ARRIVE Guidelines 76316-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 76316_Auto_Edited-LM.docx
Answering Reviewers 76316-Answering reviewers.pdf
Audio Core Tip 76316-Audio core tip.m4a
Biostatistics Review Certificate 76316-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76316-Conflict-of-interest statement.pdf
Copyright License Agreement 76316-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 76316-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 76316-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 76316-Language certificate.pdf
Peer-review Report 76316-Peer-review(s).pdf
Scientific Misconduct Check 76316-Bing-Chang KL-2.png
Scientific Editor Work List 76316-Scientific editor work list.pdf