| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Victoria Pulido-Escribano, Bárbara Torrecillas-Baena, Marta Camacho-Cardenosa, Gabriel Dorado, María Ángeles Gálvez-Moreno and Antonio Casado-Díaz |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Instituto de Salud Carlos III” (ISCIII), “Ministerio de Economía y Competitividad” (MINECO) and European Union (EU) |
PI18/01659 |
| “Instituto de Salud Carlos III” (ISCIII), “Ministerio de Economía y Competitividad” (MINECO) and European Union (EU) |
PI21/01935 |
|
| Corresponding Author |
Antonio Casado-Díaz, PhD, Research Scientist, Unidad de Gestión Clínica de Endocrinología y Nutrición-GC17, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, Avda, Menéndez Pidal, s/n, Córdoba 14004, Spain. bb1cadia@uco.es |
| Key Words |
Cell priming; Extracellular vesicles; Hypoxia; Hypoxia-inducible factor; Mesenchymal stem-cells; Regenerative medicine |
| Core Tip |
Mesenchymal stem-cells (MSC)-derived EV have a high therapeutic interest. Extracellular vesicles (EV) composition depends on the state of source cells, generating physiological changes in recipient cells. MSC culture preconditioning affects EV cargos. Thus, hypoxia exposition leads to hypoxia-inducible factor induction and regulation of hundreds of genes involved in processes such as inflammation, migration, proliferation, differentiation, angiogenesis, metabolism and apoptosis. This affects the contents of secreted EV. Accordingly, numerous studies have shown that EV from MSC under hypoxia have a higher regenerative capacity than those obtained under normoxia. Therefore, the former have a high clinical potential in different pathologies. |
| Publish Date |
2022-07-26 11:15 |
| Citation |
Pulido-Escribano V, Torrecillas-Baena B, Camacho-Cardeñosa M, Dorado G, Gálvez-Moreno MÁ, Casado-Díaz A. Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles. World J Stem Cells 2022; 14(7): 453-472 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i7/453.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i7.453 |
