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8/26/2014 2:46:00 PM | Browse: 1138 | Download: 1150
Publication Name World Journal of Gastroenterology
Manuscript ID 7667
Country/Territory Japan
Received
2013-11-28 12:06
Peer-Review Started
2013-11-28 13:03
To Make the First Decision
2013-12-16 18:06
Return for Revision
2013-12-17 15:47
Revised
2014-01-07 14:30
Second Decision
2014-01-20 18:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 19:20
Articles in Press
2014-05-23 11:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-05-30 14:19
Publish the Manuscript Online
2014-06-21 13:56
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Kouichi Miura and Hirohide Ohnishi
Funding Agency and Grant Number
Funding Agency Grant Number
JSPS to Miura K
Corresponding Author Kouichi Miura, MD, PhD, Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo Akita-shi, Akita 010-8543, Japan. miura116@doc.med.akita-u.ac.jp
Key Words Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Gut microbiota; Toll-like receptor; Probiotics; Prebiotics
Core Tip The gut-liver axis has attracted much interest particularly regarding the pathogenesis of nonalcoholic fatty liver disease (NAFLD) because gut microbiota contribute to nutritional absorption and storage. In addition, gut microbiota are a source of Toll-like receptor (TLR) ligands, which can stimulate liver cells to produce proinflammatory cytokines. To date, TLR2, TLR4, TLR5, and TLR9 have been shown to be associated with the pathogenesis of NAFLD. The present article reviewed the current understanding of gut microbiota and TLR signaling in NAFLD and potential treatment targeted at gut microbiota and TLRs.
Publish Date 2014-06-21 13:56
Citation Miura K, Ohnishi H. Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20(23): 7381-7391
URL http://www.wjgnet.com/1007-9327/full/v20/i23/7381.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i23.7381
Full Article (PDF) WJG-20-7381.pdf
Full Article (Word) WJG-20-7381.doc
Manuscript File 7667-Review.doc
Answering Reviewers 7667-Answering reviewers.pdf
Copyright License Agreement 7667-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 7667-Language certificate.pdf
Peer-review Report 7667-Peer review(s).pdf
Scientific Editor Work List 7667-Scientific editor work list.doc