Publication Name	World Journal of Stem Cells
Manuscript ID	76783
Country	China

Received	2022-03-30 14:40
Peer-Review Started	2022-03-30 14:42
To Make the First Decision
Return for Revision	2022-04-25 22:21
Revised	2022-05-04 08:42
Second Decision	2022-06-17 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 17:17
Articles in Press	2022-06-20 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-22 07:55
Publish the Manuscript Online	2022-07-26 11:15

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Na Dong, Pan-Pan Zhou, Dong Li, Hua-Su Zhu, Ling-Hong Liu, Hui-Xian Ma, Qing Shi and Xiu-Li Ju
ORCID	Author(s) ORCID Number Na Dong http://orcid.org/0000-0002-0129-5934 Pan-Pan Zhou http://orcid.org/0000-0002-1019-6436 Dong Li http://orcid.org/0000-0002-6496-4605 Hua-Su Zhu http://orcid.org/0000-0001-6432-4555 Ling-Hong Liu http://orcid.org/0000-0003-2637-0408 Hui-Xian Ma http://orcid.org/0000-0002-8147-8166 Qing Shi http://orcid.org/0000-0002-0921-3358 Xiu-Li Ju http://orcid.org/0000-0001-5464-3106
Funding Agency and Grant Number	Funding Agency Grant Number Rongxiang Regenerative Medicine Foundation of Shandong University 2019SDRX-18 Clinical Practical New Technology Development Found of Qilu Hospital of Shandong University KYC 2019-0057 Clinical Research Center of Shandong University 2020SDUCRCA010 Natural Science Foundation of Shandong Province ZR2020MH063
Corresponding Author	Xiu-Li Ju, PhD, Chief Doctor, Department of Pediatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. jxlqlyy@163.com
Key Words	Mesenchymal stem cell; Hyperoxia; Multiple organ injury; Bronchopulmonary dysplasia; Heme oxygenase-1; JAK/STAT pathway
Core Tip	In the present study, we used a newborn rat model of postnatal hyperoxia exposure to simulate clinical bronchopulmonary dysplasia (BPD) and the associated heart and kidney injuries in preterm infants. Improved lung, heart, and kidney development, as well as reduced inflammatory and oxidative responses, were observed with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) administration. We demonstrated that hUC-MSCs ameliorate hyperoxia-induced systemic organ injuries by activating heme oxygenase-1 expression and JAK/STAT pathway. Overall, our study shows that intratracheal administration is a more attractive route of MSCs administration in preterm infants for the prevention and treatment of BPD and hyperoxia-induced systemic damage.
Publish Date	2022-07-26 11:15
Citation	Dong N, Zhou PP, Li D, Zhu HS, Liu LH, Ma HX, Shi Q, Ju XL. Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways. World J Stem Cells 2022; 14(7): 556-576
URL	https://www.wjgnet.com/1948-0210/full/v14/i7/556.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i7.556

Full Article (PDF)	WJSC-14-556.pdf
Full Article (Word)	WJSC-14-556.docx
The ARRIVE Guidelines	76783-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	76783_Auto_Edited_LM.docx
Answering Reviewers	76783-Answering reviewers.pdf
Audio Core Tip	76783-Audio core tip.mp3
Biostatistics Review Certificate	76783-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	76783-Conflict-of-interest statement.pdf
Copyright License Agreement	76783-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	76783-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	76783-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	76783-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	76783-Language certificate.pdf
Peer-review Report	76783-Peer-review(s).pdf
Scientific Misconduct Check	76783-Bing-Fan JR-2.png
Scientific Editor Work List	76783-Scientific editor work list.pdf