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9/9/2022 3:45:24 PM | Browse: 241 | Download: 387
Publication Name World Journal of Diabetes
Manuscript ID 77326
Country/Territory France
Received
2022-04-25 09:38
Peer-Review Started
2022-04-25 09:39
To Make the First Decision
Return for Revision
2022-05-30 00:02
Revised
2022-06-13 17:55
Second Decision
2022-08-15 06:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-16 16:17
Articles in Press
2022-08-16 16:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-09-04 11:06
Publish the Manuscript Online
2022-09-09 15:45
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Review
Article Title A review of potential mechanisms and uses of SGLT2 inhibitors in ischemia-reperfusion phenomena
Manuscript Source Invited Manuscript
All Author List Victor Quentin, Manveer Singh and Lee S Nguyen
ORCID
Author(s) ORCID Number
Lee S Nguyen http://orcid.org/0000-0002-6014-6269
Funding Agency and Grant Number
Corresponding Author Lee S Nguyen, MD, PhD, Doctor, Senior Researcher, Research and Innovation, CMC Ambroise Paré, 25-27 Boulevard Victor Hugo, Neuilly-sur-Seine 92200, France. nguyen.lee@icloud.com
Key Words SGLT2 inhibitors; Ischemia-reperfusion injuries; Sodium-proton exchanger; Myocardial ischemia; Immunomodulation
Core Tip The antidiabetic drug-class sodium-glucose cotransporter-2 inhibitors (SGLT2i) showed efficacy in decreasing mortality in patients with chronic heart failure, in whom ischemia counts among the first cause. Remarkably, this benefit was observed independently from diabetic status. This feature, yielded from several randomized controlled trials, suggests additional effects from SGLT2i beyond isolated glycemia control. Indeed, previous in-vitro and animal models analyzed altogether suggests the role of the inhibition of the Na+/H+ exchanger, which holds a pivotal role in ischemia/reperfusion injuries. In this review, we aim to summarize evidence which associate SGLT2i and ischemia/reperfusion injuries, by first listing known mechanisms which portend the latter, and second, hypothesize how the former may interact with these mechanisms.
Publish Date 2022-09-09 15:45
Citation Quentin V, Singh M, Nguyen LS. A review of potential mechanisms and uses of SGLT2 inhibitors in ischemia-reperfusion phenomena. World J Diabetes 2022; 13(9): 683-695
URL https://www.wjgnet.com/1948-9358/full/v13/i9/683.htm
DOI https://dx.doi.org/10.4239/wjd.v13.i9.683
Full Article (PDF) WJD-13-683.pdf
Full Article (Word) WJD-13-683.docx
Manuscript File 77326_Auto_Edited-LM.docx
Answering Reviewers 77326-Answering reviewers.pdf
Audio Core Tip 77326-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 77326-Conflict-of-interest statement.pdf
Copyright License Agreement 77326-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 77326-Language certificate.pdf
Peer-review Report 77326-Peer-review(s).pdf
Scientific Misconduct Check 77326-Bing-Chang KL-2.png
Scientific Editor Work List 77326-Scientific editor work list.pdf