| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bela Veress, Niccolò Peruzzi, Marina Eckermann, Jasper Frohn, Tim Salditt, Martin Bech and Bodil Ohlsson |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Development Foundation of Region Skåne |
REGSKANE-818781, 2018-Projekt0024 |
| Foundation Skåne University Hospital |
(2020-0000028) |
|
| Corresponding Author |
Bodil Ohlsson, MD, PhD, Full Professor, Department of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms Street 15, Malmö S-205 02, Sweden. bodil.ohlsson@med.lu.se |
| Key Words |
Enteric nervous system; Immunohistochemistry; Neuropathy; Synchrotron; Virtual histology; X-ray phase-contrast nanotomography |
| Core Tip |
Full-thickness biopsies of 1 mm diameter and up to 1 cm length from the human ileum were scanned using two laboratory-based µ-computed tomography setups to study the architecture of the enteric nervous system (ENS) and further scanned by a synchrotron-based end-station for histopathological studies, without any staining. Several pathological neuronal changes, such as vacuolar degeneration, autophagic activity, appearance of sequestosomes, chromatolysis, and apoptosis, were identified in diseased patients. Phenomena that were undetectable by light microscopy were observed. The relationships among various tissue components could be followed in all directions. Thus, this method provides a unique analysis of the ENS. |
| Publish Date |
2022-08-03 07:54 |
| Citation |
Veress B, Peruzzi N, Eckermann M, Frohn J, Salditt T, Bech M, Ohlsson B. Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices. World J Gastroenterol 2022; 28(29): 3994-4006 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i29/3994.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i29.3994 |
