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8/3/2022 7:54:39 AM | Browse: 15 | Download: 37
Publication Name World Journal of Gastroenterology
Manuscript ID 77387
Country/Territory Cambodia
2022-04-28 15:09
Peer-Review Started
2022-04-28 15:12
To Make the First Decision
Return for Revision
2022-05-11 20:32
2022-05-18 12:37
Second Decision
2022-07-11 02:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-11 15:51
Articles in Press
2022-07-11 15:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-25 02:50
Publish the Manuscript Online
2022-08-03 07:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices
Manuscript Source Unsolicited Manuscript
All Author List Bela Veress, Niccolò Peruzzi, Marina Eckermann, Jasper Frohn, Tim Salditt, Martin Bech and Bodil Ohlsson
Author(s) ORCID Number
Bela Veress http://orcid.org/0000-0001-9529-6809
Niccolò Peruzzi http://orcid.org/0000-0002-2929-4247
Marina Eckermann http://orcid.org/0000-0001-6418-4310
Jasper Frohn http://orcid.org/0000-0003-3849-6032
Tim Salditt http://orcid.org/0000-0003-4636-0813
Bodil Ohlsson http://orcid.org/0000-0002-9142-5244
Funding Agency and Grant Number
Funding Agency Grant Number
Development Foundation of Region Skåne REGSKANE-818781, 2018-Projekt0024
Foundation Skåne University Hospital (2020-0000028)
Corresponding Author Bodil Ohlsson, MD, PhD, Full Professor, Department of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms Street 15, Malmö S-205 02, Sweden. bodil.ohlsson@med.lu.se
Key Words Enteric nervous system; Immunohistochemistry; Neuropathy; Synchrotron; Virtual histology; X-ray phase-contrast nanotomography
Core Tip Full-thickness biopsies of 1 mm diameter and up to 1 cm length from the human ileum were scanned using two laboratory-based µ-computed tomography setups to study the architecture of the enteric nervous system (ENS) and further scanned by a synchrotron-based end-station for histopathological studies, without any staining. Several pathological neuronal changes, such as vacuolar degeneration, autophagic activity, appearance of sequestosomes, chromatolysis, and apoptosis, were identified in diseased patients. Phenomena that were undetectable by light microscopy were observed. The relationships among various tissue components could be followed in all directions. Thus, this method provides a unique analysis of the ENS.
Publish Date 2022-08-03 07:54
Citation Veress B, Peruzzi N, Eckermann M, Frohn J, Salditt T, Bech M, Ohlsson B. Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices. World J Gastroenterol 2022; 28(29): 3994-4006
URL https://www.wjgnet.com/1007-9327/full/v28/i29/3994.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i29.3994
Full Article (PDF) WJG-28-3994.pdf
Full Article (Word) WJG-28-3994.docx
Manuscript File 77387_Auto_Edited-LM.docx
Answering Reviewers 77387-Answering reviewers.pdf
Audio Core Tip 77387-Audio core tip.mp3
Biostatistics Review Certificate 77387-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 77387-Conflict-of-interest statement.pdf
Copyright License Agreement 77387-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 77387-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 77387-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 77387-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 77387-Language certificate.pdf
Supplementary Material 77387-Supplementary material.zip
Peer-review Report 77387-Peer-review(s).pdf
Scientific Misconduct Check 77387-Bing-Chen YL-2.png
Scientific Editor Work List 77387-Scientific editor work list.pdf