Publication Name	World Journal of Gastroenterology
Manuscript ID	7753
Country

Received	2013-11-30 13:03
Peer-Review Started	2013-12-02 16:15
To Make the First Decision	2014-02-14 12:44
Return for Revision	2014-02-20 14:10
Revised	2014-03-18 17:48
Second Decision	2014-07-16 12:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-07-16 13:02
Articles in Press	2014-07-16 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-03 11:23
Publish the Manuscript Online	2014-09-19 19:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Early-onset colorectal cancer: A sporadic or inherited disease?
Manuscript Source
All Author List	Vittoria Stigliano, Lupe Sanchez-Mete, Aline Martayan and Marcello Anti
Funding Agency and Grant Number
Corresponding Author	Vittoria Stigliano, MD, Division of Gastroenterology and Digestive Endoscopy, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy. stigliano@ifo.it
Key Words	Early-onset colorectal cancer; Epidemiology; Hereditary syndrome; Lynch syndrome; MUTYH-associated polyposis
Core Tip	The phenotypic and genotypic heterogeneity of early-onset colorectal cancers (CRCs) clearly emerges from clinical studies. We can distinguish two distinct entities, an inherited subtype, usually with familial aggregation, accounting for a relatively low percentage of cases, with specific clinicopathologic features and a “sporadic” subtype, often without family history of CRC, with distinct location and histopathologic features. There is a significant variability in the mechanisms underlying the development of early-onset CRC and it is certainly a big concern for clinicians and oncologists for the implications on prevention, diagnosis and clinical management of the disease.
Publish Date	2014-09-19 19:25
Citation	Stigliano V, Sanchez-Mete L, Martayan A, Anti M. Early-onset colorectal cancer: A sporadic or inherited disease? World J Gastroenterol 2014; 20(35): 12420-12430
URL	http://www.wjgnet.com/1007-9327/full/v20/i35/12420.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i35.12420

Full Article (PDF)	WJG-20-12420.pdf
Full Article (Word)	WJG-20-12420.doc
Manuscript File	7753-Review.doc
Answering Reviewers	7753-Answering reviewers.pdf
Copyright License Agreement	7753-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131129002059.doc
Peer-review Report	7753-Peer reviews.pdf
Scientific Misconduct Check	7753-CrossCheck.jpg
Scientific Editor Work List	7753-Scientific editor work list.pdf