Publication Name	World Journal of Gastroenterology
Manuscript ID	7757
Country	China

Received	2013-11-30 13:12
Peer-Review Started	2013-12-02 14:34
To Make the First Decision	2014-01-15 19:15
Return for Revision	2014-01-20 22:28
Revised	2014-02-13 23:43
Second Decision	2014-03-06 17:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-06 18:25
Articles in Press	2014-05-23 09:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-18 16:27
Typeset the Manuscript	2014-05-22 15:48
Publish the Manuscript Online	2014-06-16 16:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Autobiography
Article Title	Evaluation of a novel choanoid fluidized bed bioreactor for future bioartificial livers
Manuscript Source	Invited Manuscript
All Author List	Cheng-Bo Yu, Xiao-Ping Pan, Liang Yu, Xiao-Peng Yu, Wei-Bo Du, Hong-Cui Cao, Jun Li, Ping Chen and Lan-Juan Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 2011ZX10004-901 National Natural Science Foundation of China 2013ZX10004904 National Science and Technology Major Project 2012ZX10002006
Corresponding Author	Lan-Juan Li, MD, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn
Key Words	Choanoid; Fluidized bed; Bioreactor; Immortalized human hepatocytes; Bioartificial liver
Core Tip	We constructed a novel choanoid fluidized bed bioreactor (CFBB) and received a national invention patent. We evaluated the CFBB functionality based on microencapsulated immortalized human hepatocytes. For this purpose, we placed the cultured hepatocytes into the CFBB and circulated through Dulbecco’s Modified Eagle’s Medium media for 12 h and through exchanged plasma for 6 h. The bioartificial liver based on a fluidized-bed bioreactor with microencapsulated immortalized human hepatocytes appeared to be effective for improving severe hepatitis plasma parameters. The efficacy of this novel bioreactor is promising for the study of liver failure.
Publish Date	2014-06-16 16:19
Citation	Yu CB, Pan XP, Yu L, Yu XP, Du WB, Cao HC, Li J, Chen P, Li LJ. Evaluation of a novel choanoid fluidized bed bioreactor for future bioartificial livers. World J Gastroenterol 2014; 20(22): 6869-6877
URL	http://www.wjgnet.com/1007-9327/full/v20/i22/6869.htm
DOI	10.3748/wjg.v20.i22.6869

Full Article (PDF)	WJG-20-6869.pdf
Full Article (Word)	WJG-20-6869.doc
Manuscript File	7757-Review.doc
Answering Reviewers	7757-Answering reviewers.pdf
Copyright License Agreement	7757-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7757-Language certificate.PDF
Peer-review Report	7757-Peer review(s).pdf
Scientific Editor Work List	7757-Scientific editor work list.doc