ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Xiu-Min Wang, Li-Xia Lv, Yue-Si Qin, Yu-Zhu Zhang, Ni Yang, Shu Wu, Xiu-Wen Xia, Hong Yang, Hong Xu, Ying Liu and Wei-Jun Ding |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
82074151 |
Experimental Formulary Sichuan Youth Science and Technology Innovation Research Team |
2020JDTD0022 |
|
Corresponding Author |
Wei-Jun Ding, PhD, Full Professor, Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu 610072, Sichuan Province, China. dingweijun@cdutcm.edu.cn |
Key Words |
Slow-transit constipation; Ji-Chuan decoction; Taurine and hypotaurine metabolism; AKT; Enteric glial cell; Apoptosis |
Core Tip |
Slow transit constipation (STC) model mice, which were established with compound diphenoxylate, were effectively treated with Ji-Chuan decoction (JCD). The results show that JCD can promote intestinal motility, increase acetylcholine content, reduce enteric inflammation, improve metabolic dysfunction, and reduce enteric glial cell apoptosis. This work demonstrated that reducing enteric glial cell apoptosis may be the critical mechanism by which JCD treats STC. These findings call for further molecular research to facilitate the clinical application of JCD. |
Publish Date |
2022-09-07 08:29 |
Citation |
Wang XM, Lv LX, Qin YS, Zhang YZ, Yang N, Wu S, Xia XW, Yang H, Xu H, Liu Y, Ding WJ. Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis. World J Gastroenterol 2022; 28(34): 5007-5022 |
URL |
https://www.wjgnet.com/1007-9327/full/v28/i34/5007.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v28.i34.5007 |