BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/7/2022 8:29:04 AM | Browse: 254 | Download: 483
Publication Name World Journal of Gastroenterology
Manuscript ID 77778
Country/Territory China
Received
2022-05-20 03:33
Peer-Review Started
2022-05-20 03:36
To Make the First Decision
Return for Revision
2022-07-13 00:11
Revised
2022-07-19 11:47
Second Decision
2022-08-19 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-21 17:47
Articles in Press
2022-08-21 17:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-08-28 23:45
Publish the Manuscript Online
2022-09-07 08:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis
Manuscript Source Unsolicited Manuscript
All Author List Xiu-Min Wang, Li-Xia Lv, Yue-Si Qin, Yu-Zhu Zhang, Ni Yang, Shu Wu, Xiu-Wen Xia, Hong Yang, Hong Xu, Ying Liu and Wei-Jun Ding
ORCID
Author(s) ORCID Number
Xiu-Min Wang http://orcid.org/0000-0002-3088-8579
Li-Xia Lv http://orcid.org/0000-0001-5216-1605
Yue-Si Qin http://orcid.org/0000-0002-5327-9554
Yu-Zhu Zhang http://orcid.org/0000-0001-6779-0711
Ni Yang http://orcid.org/0000-0002-5613-6041
Shu Wu http://orcid.org/0000-0002-8729-8801
Xiu-Wen Xia http://orcid.org/0000-0003-1962-1221
Hong Yang http://orcid.org/0000-0002-5145-4243
Hong Xu http://orcid.org/0000-0002-3905-7835
Ying Liu http://orcid.org/0000-0002-3318-3486
Wei-Jun Ding http://orcid.org/0000-0002-4933-7347
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82074151
Experimental Formulary Sichuan Youth Science and Technology Innovation Research Team 2020JDTD0022
Corresponding Author Wei-Jun Ding, PhD, Full Professor, Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Avenue, Wenjiang District, Chengdu 610072, Sichuan Province, China. dingweijun@cdutcm.edu.cn
Key Words Slow-transit constipation; Ji-Chuan decoction; Taurine and hypotaurine metabolism; AKT; Enteric glial cell; Apoptosis
Core Tip Slow transit constipation (STC) model mice, which were established with compound diphenoxylate, were effectively treated with Ji-Chuan decoction (JCD). The results show that JCD can promote intestinal motility, increase acetylcholine content, reduce enteric inflammation, improve metabolic dysfunction, and reduce enteric glial cell apoptosis. This work demonstrated that reducing enteric glial cell apoptosis may be the critical mechanism by which JCD treats STC. These findings call for further molecular research to facilitate the clinical application of JCD.
Publish Date 2022-09-07 08:29
Citation Wang XM, Lv LX, Qin YS, Zhang YZ, Yang N, Wu S, Xia XW, Yang H, Xu H, Liu Y, Ding WJ. Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis. World J Gastroenterol 2022; 28(34): 5007-5022
URL https://www.wjgnet.com/1007-9327/full/v28/i34/5007.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i34.5007
Full Article (PDF) WJG-28-5007.pdf
Full Article (Word) WJG-28-5007.docx
The ARRIVE Guidelines 77778-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 77778_Auto_Edited-LS.docx
Answering Reviewers 77778-Answering reviewers.pdf
Audio Core Tip 77778-Audio core tip.mp3
Biostatistics Review Certificate 77778-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 77778-Conflict-of-interest statement.pdf
Copyright License Agreement 77778-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 77778-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 77778-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 77778-Language certificate.pdf
Supplementary Material 77778-Supplementary material.pdf
Peer-review Report 77778-Peer-review(s).pdf
Scientific Misconduct Check 77778-Bing-Wang JJ-2.png
Scientific Editor Work List 77778-Scientific editor work list.pdf