| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Prevention of esophageal strictures after endoscopic submucosal dissection
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shinichiro Kobayashi, Nobuo Kanai, Takeshi Ohki, Ryo Takagi, Naoyuki Yamaguchi, Hajime Isomoto, Yoshiyuki Kasai, Takahiro Hosoi, Kazuhiko Nakao, Susumu Eguchi, Masakazu Yamamoto, Masayuki Yamato and Teruo Okano |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program that was part of the Project for Developing Innovation Systems by the Cell Sheet Tissue Engineering Center from the Ministry of Education, Culture, Sports, Science and Technology, Japan |
|
|
| Corresponding Author |
Teruo Okano, PhD, Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. tokano@abmes.twmu.ac.jp |
| Key Words |
Endoscopic submucosal dissection; Esophageal stricture; Systemic steroid therapy; Autologous oral mucosal epithelial cell sheet |
| Core Tip |
Esophageal strictures after extensive endoscopic submucosal dissection (ESD) reduce quality of life. Endoscopic local injections and the oral administration of steroids are safe and effective for preventing esophageal strictures. In addition, several tissue engineering therapies have been used in attempts to overcome severe esophageal strictures. Cell-based tissue engineering therapy with fabricated autologous oral mucosal epithelial cell sheets has been used to prevent esophageal strictures after ESD in nine patients. This therapy has been shown to be safe and may be widely used in the future. |
| Publish Date |
2014-11-10 19:10 |
| Citation |
Kobayashi S, Kanai N, Ohki T, Takagi R, Yamaguchi N, Isomoto H, Kasai Y, Hosoi T, Nakao K, Eguchi S, Yamamoto M, Yamato M, Okano T. Prevention of esophageal strictures after endoscopic submucosal dissection. World J Gastroenterol 2014; 20(41): 15098-15109 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i41/15098.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i41.15098 |
